Intravenous streptokinase treatment and serum C-reactive protein in patients with acute myocardial infarction.

K Pietilä, A Harmoinen, L Pöyhönen, M Koskinen, J Heikkila, R Ruosteenoja

Department of Medicine, Tampere University Central Hospital, Finland.

Serum concentrations of C-reactive protein were studied in 23 patients with acute myocardial infarction. In 14 patients who did not receive thrombolytic treatment there was a linear relation between infarct size (determined by serial creatine kinase-MB determinations and thallium-201 isotope emission tomography) and the C-reactive protein response. The correlation coefficient between the concentration-time integrals of creatine kinase-MB and C-reactive protein was 0.96. The correlation coefficient between the creatine kinase-MB concentration-time integral and the peak serum value of C-reactive protein was 0.93. In the nine patients who received intravenous streptokinase treatment there was also a positive correlation between the concentration-time integrals of creatine kinase-MB and C-reactive protein. The relation, however, depended on the success of the treatment. In patients with successful reperfusion the C-reactive protein response was only approximately 20% of that in patients in whom reperfusion failed or who received no thrombolytic treatment and who were matched by infarct size. When thrombolysis was successful the correlation coefficient between the concentration-time integrals of creatine kinase-MB and C-reactive protein was 0.86. Daily measurement of serum C-reactive protein is useful in evaluating infarct size in patients with acute myocardial infarction who do not receive thrombolytic treatment. In patients treated with streptokinase C-reactive protein concentrations may be used to assess the success of thrombolysis.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Ziakas, A., Gavrilidis, S., Giannoglou, G., Souliou, E., Gemitzis, K., Kalampalika, D., Vayona, M. A., Pidonia, I., Parharidis, G., Louridas, G. (2006). In-Hospital and Long-Term Prognostic Value of Fibrinogen, CRP, and IL-6 Levels in Patients with Acute Myocardial Infarction Treated with Thrombolysis. ANGIOLOGY 57: 283-293 [Abstract]  
• Dibra, A., Mehilli, J., Schwaiger, M., Schuhlen, H., Bollwein, H., Braun, S., Neverve, J., Schomig, A., Kastrati, A. (2003). Predictive value of basal C-reactive protein levels for myocardial salvage in patients with acute myocardial infarction is dependent on the type of reperfusion treatment. Eur Heart J 24: 1128-1133 [Abstract] [Full Text]  
• de Winter, R. J., Fischer, J., Bholasingh, R., van Straalen, J. P., de Jong, T., Tijssen, J. G.P., Sanders, G. T. (2000). C-Reactive Protein and Cardiac Troponin T in Risk Stratification: Differences in Optimal Timing of Tests Early after the Onset of Chest Pain. Clin. Chem. 46: 1597-1603 [Abstract] [Full Text]  
• Tataru, M.-C, Heinrich, J, Junker, R, Schulte, H, von Eckardstein, A, Assmann, G, Koehler, E (2000). C-reactive protein and the severity of atherosclerosis in myocardial infarction patients with stable angina pectoris. Eur Heart J 21: 1000-1008 [Abstract]  
• Lagrand, W. K., Visser, C. A., Hermens, W. T., Niessen, H. W. M., Verheugt, F. W. A., Wolbink, G.-J., Hack, C. E. (1999). C-Reactive Protein as a Cardiovascular Risk Factor : More Than an Epiphenomenon?. Circulation 100: 96-102 [Abstract] [Full Text]