The effect of treatment of congestive heart failure on plasma atrial natriuretic peptide concentration: a longitudinal study.

J V Anderson, P W Woodruff, S R Bloom

Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London.

Eleven patients with acute congestive heart failure were studied during treatment with a loop diuretic. Plasma concentrations of atrial natriuretic peptide were considerably increased before treatment and with successful treatment returned progressively towards normal values. There was a statistically significant correlation between plasma atrial natriuretic peptide concentration and both jugular venous pressure and change of body weight. These results support the hypothesis that atrial distension is an important stimulus to atrial natriuretic peptide release. Furthermore, the close relation between plasma concentrations of atrial natriuretic peptide and clinical improvement in these patients suggests that measurement of plasma atrial natriuretic peptide concentration could provide a clinically useful and non-invasive method of monitoring the response to treatment.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Smith, J. A., Bruusgaard, D., Bodd, E., Hall, C. (2001). Relations between medical history, clinical findings and plasma N-terminal proatrial natriuretic peptide in patients in primary health care. Eur J Heart Fail 3: 307-313 [Abstract] [Full Text]  
• Stefanec, T. (2000). Endothelial Apoptosis: Could It Have a Role in the Pathogenesis and Treatment of Disease?. Chest 117: 841-854 [Abstract] [Full Text]  
• Dutka, D. P., Puri, S., Strong, R., Cleland, J. G.F. (1999). Disruption of the relationship between renin and atrial natriuretic peptide early in the course of ventricular dysfunction. Eur J Heart Fail 1: 371-377 [Abstract] [Full Text]  
• Davis, K. M., Fish, L. C., Elahi, D., Clark, B. A., Minaker, K. L. (1992). Atrial Natriuretic Peptide Levels in the Prediction of Congestive Heart Failure Risk in Frail Elderly. JAMA 267: 2625-2629 [Abstract]