Tumour necrosis factor alpha in severe congestive cardiac failure.

D P Dutka, J S Elborn, F Delamere, D J Shale, G K Morris

City Hospital, Nottingham.

OBJECTIVE--To examine the concentration of circulating tumour necrosis factor alpha (TNF alpha) in patients with severe congestive heart failure (New York Heart Association class IV) during one year and to correlate changes in this cytokine with changes in plasma noradrenaline, plasma renin activity, and weight. DESIGN--A prospective study of the role of TNF alpha in severe chronic heart failure. Blood samples were collected at intervals of three months. SETTING--Medical research centre of a teaching hospital. PATIENTS--16 patients with chronic stable severe heart failure. INTERVENTIONS--Vasodilator treatment with captopril or flosequinan. MAIN OUTCOME MEASURES--Changes in TNF alpha and the correlation with changes in plasma noradrenaline, plasma renin activity, and weight during optimal medical treatment for one year. RESULTS--The mean concentration of TNF alpha was greater than the upper 95% confidence interval for healthy controls throughout the year of the study but there was considerable between and within patient variation. No correlation was seen between TNF alpha and plasma noradrenaline, plasma renin activity, or weight. CONCLUSIONS--The stimulus resulting in enhanced plasma concentrations of TNF alpha in congestive heart failure remains unclear and concentrations at any particular time were not prognostic.

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• Anker, S. D., Coats, A. J. S. (1999). Cardiac Cachexia: A Syndrome With Impaired Survival and Immune and Neuroendocrine Activation. Chest 115: 836-847 [Abstract] [Full Text]  
• Horio, T., Nishikimi, T., Yoshihara, F., Nagaya, N., Matsuo, H., Takishita, S., Kangawa, K. (1998). Production and Secretion of Adrenomedullin in Cultured Rat Cardiac Myocytes and Nonmyocytes: Stimulation by Interleukin-1{beta} and Tumor Necrosis Factor-{alpha}. Endocrinology 139: 4576-4580 [Abstract] [Full Text]  
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• Ferrari, R. (1998). Tumor necrosis factor in CHF: a double facet cytokine. Cardiovasc Res 37: 554-559 [Full Text]  
• Kubota, T., McTiernan, C. F., Frye, C. S., Slawson, S. E., Lemster, B. H., Koretsky, A. P., Demetris, A. J., Feldman, A. M. (1997). Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-{alpha}. Circ. Res. 81: 627-635 [Abstract] [Full Text]  
• Kapadia, S. R., Oral, H., Lee, J., Nakano, M., Taffet, G. E., Mann, D. L. (1997). Hemodynamic Regulation of Tumor Necrosis Factor-{alpha} Gene and Protein Expression in Adult Feline Myocardium. Circ. Res. 81: 187-195 [Abstract] [Full Text]  
• Anker, S. D., Chua, T. P., Ponikowski, P., Harrington, D., Swan, J. W., Kox, W. J., Poole-Wilson, P. A., Coats, A. J. S. (1997). Hormonal Changes and Catabolic/Anabolic Imbalance in Chronic Heart Failure and Their Importance for Cardiac Cachexia. Circulation 96: 526-534 [Abstract] [Full Text]  
• Kelly, R. A., Smith, T. W. (1997). Cytokines and Cardiac Contractile Function. Circulation 95: 778-781 [Full Text]  
• Brasier, A. R., Li, J., Wimbish, K. A. (1996). Tumor Necrosis Factor Activates Angiotensinogen Gene Expression by the Rel A Transactivator. Hypertension 27: 1009-1017 [Abstract] [Full Text]  
• Torre-Amione, G., Kapadia, S., Lee, J., Durand, J.-B., Bies, R. D., Young, J. B., Mann, D. L. (1996). Tumor Necrosis Factor-{alpha} and Tumor Necrosis Factor Receptors in the Failing Human Heart. Circulation 93: 704-711 [Abstract] [Full Text]  
• Packer, M. (1995). Is Tumor Necrosis Factor an Important Neurohormonal Mechanism in Chronic Heart Failure?. Circulation 92: 1379-1382 [Full Text]  
• Ferrari, R., Bachetti, T., Confortini, R., Opasich, C., Febo, O., Corti, A., Cassani, G., Visioli, O. (1995). Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure. Circulation 92: 1479-1486 [Abstract] [Full Text]  
• Torre-Amione, G., Kapadia, S., Lee, J., Bies, R. D., Lebovitz, R., Mann, D. L. (1995). Expression and Functional Significance of Tumor Necrosis Factor Receptors in Human Myocardium. Circulation 92: 1487-1493 [Abstract] [Full Text]