Increased circulating cytokines in patients with myocarditis and cardiomyopathy.

A Matsumori, T Yamada, H Suzuki, Y Matoba, S Sasayama

Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

OBJECTIVES--To elucidate the potential role of cytokines in the pathogenesis of cardiomyopathy and myocarditis. BACKGROUND--Experimental studies show that certain cytokines depress myocardial contractility and that tumour necrosis factor-alpha plays an important part in the pathogenesis of myocardial injury in animal models of viral and autoimmune myocarditis. METHODS--Plasma interleukin 1-alpha, interleukin 1-beta, interleukin-2, interleukin-6, tumour necrosis factor-alpha, tumour necrosis factor-beta, granulocyte-macrophage colony stimulating factor, granulocyte colony stimulating factor, macrophage colony stimulating factor, interferon-alpha and interferon-gamma were measured in 13 patients with acute myocarditis, 23 patients with dilated cardiomyopathy, 51 patients with hypertrophic cardiomyopathy, nine patients with acute myocardial infarction, 18 patients with angina pectoris, 12 patients with essential hypertension and 17 healthy controls. RESULTS--Increased concentrations of cytokines were not detected in the controls. In patients with acute myocarditis, interleukin 1-alpha was detected in 23% (mean (SD) 25 (11) pg/ml), tumour necrosis factor-alpha in 46% (61 (31) pg/ml), and macrophage colony stimulating factor was 2.5 (1.8) ng/ml (normal 1.9 (0.4)). In patients with dilated cardiomyopathy, tumour necrosis factor-alpha was detected in 35% (402 (555) pg/ml). In patients with hypertrophic cardiomyopathy, interleukin-2 was detectable in 14% (2318 (4738) pg/ml) and tumour necrosis factor-alpha ws detected in 20% (992 (1517) pg/ml). The concentration of macrophage colony stimulating factor was raised in patients with acute myocardial infarction. Granulocyte colony stimulating factor was often increased in myocarditis, cardiomyopathies, acute myocardial infarction, and angina pectoris--suggesting activation of macrophages and/or endothelial cells--but this increase was not specific to these diseases. Increased concentrations of cytokines were not found in patients with essential hypertension. CONCLUSION--These results suggest that cytokines may play a part in the pathogenesis of myocardial injury in myocarditis and cardiomyopathies and that further studies to explore the potential pathogenetic role of cytokines in myocardial diseases may be warranted.

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• Felix, S.B., Staudt, A., Baumann, G. (2002). Immunoadsorption as a new therapeutic principle for treatment of dilated cardiomyopathy. Eur Heart J Suppl 4: I63-I68 [Abstract]  
• Bradham, W. S., Bozkurt, B., Gunasinghe, H., Mann, D., Spinale, F. G. (2002). Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current perspective. Cardiovasc Res 53: 822-830 [Abstract] [Full Text]  
• Densem, C G, Hutchinson, I V, Yonan, N, Brooks, N H (2002). Tumour necrosis factor {alpha} gene polymorphism: a predisposing factor to non-ischaemic myocardial dysfunction?. Heart 87: 153-155 [Abstract] [Full Text]  
• Adamopoulos, S., Parissis, J. T., Kremastinos, D. Th. (2001). A glossary of circulating cytokines in chronic heart failure. Eur J Heart Fail 3: 517-526 [Abstract] [Full Text]  
• Triboulot, C., Hichami, A., Denys, A., Khan, N. A. (2001). Dietary (n-3) Polyunsaturated Fatty Acids Exert Antihypertensive Effects by Modulating Calcium Signaling in T Cells of Rats. J. Nutr. 131: 2364-2369 [Abstract] [Full Text]  
• Liu, P. P., Mason, J. W. (2001). Advances in the Understanding of Myocarditis. Circulation 104: 1076-1082 [Full Text]  
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• Nagueh, S. F., Stetson, S. J., Lakkis, N. M., Killip, D., Perez-Verdia, A., Entman, M. L., Spencer, W. H. III, Torre-Amione, G. (2001). Decreased Expression of Tumor Necrosis Factor-{{alpha}} and Regression of Hypertrophy After Nonsurgical Septal Reduction Therapy for Patients With Hypertrophic Obstructive Cardiomyopathy. Circulation 103: 1844-1850 [Abstract] [Full Text]  
• Graciano, A. L., Bryant, D. D., White, D. J., Horton, J., Bowles, N. E., Giroir, B. P. (2001). Targeted disruption of ICAM-1, P-selectin genes improves cardiac function and survival in TNF-{alpha} transgenic mice. Am. J. Physiol. Heart Circ. Physiol. 280: H1464-H1471 [Abstract] [Full Text]  
• Hiraoka, E., Kawashima, S., Takahashi, T., Rikitake, Y., Kitamura, T., Ogawa, W., Yokoyama, M. (2001). TNF-{alpha} induces protein synthesis through PI3-kinase-Akt/PKB pathway in cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 280: H1861-H1868 [Abstract] [Full Text]  
• Mann, D. L. (2001). Tumor Necrosis Factor and Viral Myocarditis: The Fine Line Between Innate and Inappropriate Immune Responses in the Heart. Circulation 103: 626-629 [Full Text]  
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• Ohtsuka, T., Hamada, M., Hiasa, G., Sasaki, O., Suzuki, M., Hara, Y., Shigematsu, Y., Hiwada, K. (2001). Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy. J Am Coll Cardiol 37: 412-417 [Abstract] [Full Text]  
• Fuse, K., Kodama, M., Okura, Y., Ito, M., Hirono, S., Kato, K., Hanawa, H., Aizawa, Y. (2000). Predictors of Disease Course in Patients With Acute Myocarditis. Circulation 102: 2829-2835 [Abstract] [Full Text]  
• Bozkurt, B. (2000). Activation of cytokines as a mechanism of disease progression in heart failure. Ann Rheum Dis 59: i90-93 [Full Text]  
• Takano, H., Nagai, T., Asakawa, M., Toyozaki, T., Oka, T., Komuro, I., Saito, T., Masuda, Y. (2000). Peroxisome Proliferator-Activated Receptor Activators Inhibit Lipopolysaccharide-Induced Tumor Necrosis Factor-{alpha} Expression in Neonatal Rat Cardiac Myocytes. Circ. Res. 87: 596-602 [Abstract] [Full Text]  
• Birks, E. J., Owen, V. J., Burton, P. B. J., Bishop, A. E., Banner, N. R., Khaghani, A., Polak, J. M., Yacoub, M. H. (2000). Tumor Necrosis Factor-{alpha} Is Expressed in Donor Heart and Predicts Right Ventricular Failure After Human Heart Transplantation. Circulation 102: 326-331 [Abstract] [Full Text]  
• Kapadia, S. R., Yakoob, K., Nader, S., Thomas, J. D., Mann, D. L., Griffin, B. P. (2000). Elevated circulating levels of serum tumor necrosis factor-alpha in patients with hemodynamically significant pressure and volume overload. J Am Coll Cardiol 36: 208-212 [Abstract] [Full Text]  
• Felix, S. B., Staudt, A., Dorffel, W. V., Stangl, V., Merkel, K., Pohl, M., Docke, W. D., Morgera, S., Neumayer, H. H., Wernecke, K. D., Wallukat, G., Stangl, K., Baumann, G. (2000). Hemodynamic effects of immunoadsorption and subsequent immunoglobulin substitution in dilated cardiomyopathy: Three-month results from a randomized study. J Am Coll Cardiol 35: 1590-1598 [Abstract] [Full Text]  
• Heim, A., Zeuke, S., Weiss, S., Ruschewski, W., Grumbach, I. M. (2000). Transient Induction of Cytokine Production in Human Myocardial Fibroblasts by Coxsackievirus B3. Circ. Res. 86: 753-759 [Abstract] [Full Text]  
• Feldman, A. M., Combes, A., Wagner, D., Kadakomi, T., Kubota, T., You Li, Y., McTiernan, C. (2000). The role of tumor necrosis factor in the pathophysiology of heart failure. J Am Coll Cardiol 35: 537-544 [Abstract] [Full Text]  
• Gullestad, L., Aukrust, P.a., Ueland, T., Espevik, T., Yee, G., Vagelos, R., Froland, S. S., Fowler, M. (1999). Effect of high- versus low-dose angiotensin converting enzyme inhibition on cytokine levels in chronic heart failure. J Am Coll Cardiol 34: 2061-2067 [Abstract] [Full Text]  
• Young, J. B. (1999). Angiotensin-converting enzyme inhibitors and cytokines in heart failure: dose and effect?. J Am Coll Cardiol 34: 2068-2071 [Full Text]  
• Azzawi, M., Hasleton, P. (1999). Tumour necrosis factor alpha and the cardiovascular system: its role in cardiac allograft rejection and heart disease. Cardiovasc Res 43: 850-859 [Full Text]  
• Ishiyama, S., Hiroe, M., Nishikawa, T., Shimojo, T., Hosokawa, T., Ikeda, I., Toyozaki, T., Kasajima, T., Marumo, F. (1999). Inhibitory effects of vesnarinone in the progression of myocardial damage in experimental autoimmune myocarditis in rats. Cardiovasc Res 43: 389-397 [Abstract] [Full Text]  
• Francis, G. S. (1999). TNF-{alpha} and Heart Failure : The Difference Between Proof of Principle and Hypothesis Testing. Circulation 99: 3213-3214 [Full Text]  
• Yokoyama, T., Sekiguchi, K., Tanaka, T., Tomaru, K., Arai, M., Suzuki, T., Nagai, R. (1999). Angiotensin II and mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts. Am. J. Physiol. Heart Circ. Physiol. 276: H1968-H1976 [Abstract] [Full Text]  
• Sasayama, S., Matsumori, A., Kihara, Y. (1999). New insights into the pathophysiological role for cytokines in heart failure. Cardiovasc Res 42: 557-564 [Full Text]  
• Li, D., Yang, B., L. Mehta, J. (1999). Tumor necrosis factor-{alpha} enhances hypoxia-reoxygenation-mediated apoptosis in cultured human coronary artery endothelial cells: critical role of protein kinase C. Cardiovasc Res 42: 805-813 [Abstract] [Full Text]  
• Pinto, J. M.B, Boyden, P. A (1999). Electrical remodeling in ischemia and infarction. Cardiovasc Res 42: 284-297 [Abstract] [Full Text]  
• Iwasaki, A., Matsumori, A., Yamada, T., Shioi, T., Wang, W., Ono, K., Nishio, R., Okada, M., Sasayama, S. (1999). Pimobendan inhibits the production of proinflammatory cytokines and gene expression of inducible nitric oxide synthase in a murine model of viral myocarditis. J Am Coll Cardiol 33: 1400-1407 [Abstract] [Full Text]  
• Irwin, M. W., Mak, S., Mann, D. L., Qu, R., Penninger, J. M., Yan, A., Dawood, F., Wen, W.-H., Shou, Z., Liu, P. (1999). Tissue Expression and Immunolocalization of Tumor Necrosis Factor-{alpha} in Postinfarction Dysfunctional Myocardium. Circulation 99: 1492-1498 [Abstract] [Full Text]  
• Kawai, C. (1999). From Myocarditis to Cardiomyopathy: Mechanisms of Inflammation and Cell Death : Learning From the Past for the Future. Circulation 99: 1091-1100 [Abstract] [Full Text]  
• Nishio, R., Matsumori, A., Shioi, T., Wang, W., Yamada, T., Ono, K., Sasayama, S. (1998). Denopamine, a {beta}1-adrenergic agonist, prolongs survival in a murine model of congestive heart failure induced by viral myocarditis: suppression of tumor necrosis factor-{alpha} production in the heart. J Am Coll Cardiol 32: 808-815 [Abstract] [Full Text]  
• Nakamura, K., Fushimi, K., Kouchi, H., Mihara, K., Miyazaki, M., Ohe, T., Namba, M. (1998). Inhibitory Effects of Antioxidants on Neonatal Rat Cardiac Myocyte Hypertrophy Induced by Tumor Necrosis Factor-{alpha} and Angiotensin II. Circulation 98: 794-799 [Abstract] [Full Text]  
• Fukuchi, M., Hussain, S. N. A., Giaid, A. (1998). Heterogeneous Expression and Activity of Endothelial and Inducible Nitric Oxide Synthases in End-Stage Human Heart Failure : Their Relation to Lesion Site and ß-Adrenergic Receptor Therapy. Circulation 98: 132-139 [Abstract] [Full Text]  
• Ono, K., Matsumori, A., Shioi, T., Furukawa, Y., Sasayama, S. (1998). Cytokine Gene Expression After Myocardial Infarction in Rat Hearts : Possible Implication in Left Ventricular Remodeling. Circulation 98: 149-156 [Abstract] [Full Text]  
• Suto, N., Mikuniya, A., Okubo, T., Hanada, H., Shinozaki, N., Okumura, K. (1998). Nitric oxide modulates cardiac contractility and oxygen consumption without changing contractile efficiency. Am. J. Physiol. Heart Circ. Physiol. 275: H41-H49 [Abstract] [Full Text]  
• Yue, P., Massie, B. M., Simpson, P. C., Long, C. S. (1998). Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure. Am. J. Physiol. Heart Circ. Physiol. 275: H250-H258 [Abstract] [Full Text]  
• Bryant, D., Becker, L., Richardson, J., Shelton, J., Franco, F., Peshock, R., Thompson, M., Giroir, B. (1998). Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-{alpha}. Circulation 97: 1375-1381 [Abstract] [Full Text]  
• Nakano, M., Knowlton, A. A., Dibbs, Z., Mann, D. L. (1998). Tumor Necrosis Factor-{alpha} Confers Resistance to Hypoxic Injury in the Adult Mammalian Cardiac Myocyte. Circulation 97: 1392-1400 [Abstract] [Full Text]  
• Ferrari, R. (1998). Tumor necrosis factor in CHF: a double facet cytokine. Cardiovasc Res 37: 554-559 [Full Text]  
• Shioi, T., Matsumori, A., Kihara, Y., Inoko, M., Ono, K., Iwanaga, Y., Yamada, T., Iwasaki, A., Matsushima, K., Sasayama, S. (1997). Increased Expression of Interleukin-1ß and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload. Circ. Res. 81: 664-671 [Abstract] [Full Text]  
• Juvonen, J., Surcel, H.-M., Satta, J., Teppo, A.-M., Bloigu, A., Syrjala, H., Airaksinen, J., Leinonen, M., Saikku, P., Juvonen, T. (1997). Elevated Circulating Levels of Inflammatory Cytokines in Patients With Abdominal Aortic Aneurysm. Arterioscler. Thromb. Vasc. Bio. 17: 2843-2847 [Abstract] [Full Text]  
• Kubota, T., McTiernan, C. F., Frye, C. S., Slawson, S. E., Lemster, B. H., Koretsky, A. P., Demetris, A. J., Feldman, A. M. (1997). Dilated Cardiomyopathy in Transgenic Mice With Cardiac-Specific Overexpression of Tumor Necrosis Factor-{alpha}. Circ. Res. 81: 627-635 [Abstract] [Full Text]  
• Matsumori, A., Ono, K., Nishio, R., Nose, Y., Sasayama, S. (1997). Amiodarone Inhibits Production of Tumor Necrosis Factor-{alpha} by Human Mononuclear Cells : A Possible Mechanism for its Effect in Heart Failure. Circulation 96: 1386-1389 [Abstract] [Full Text]  
• Matsumori, A., Ono, K., Nishio, R., Igata, H., Pharm, B, Shioi, T., Matsui, S., Furukawa, Y., Iwasaki, A., Nose, Y., Sasayama, S. (1997). Modulation of Cytokine Production and Protection Against Lethal Endotoxemia by the Cardiac Glycoside Ouabain. Circulation 96: 1501-1506 [Abstract] [Full Text]  
• Kapadia, S. R., Oral, H., Lee, J., Nakano, M., Taffet, G. E., Mann, D. L. (1997). Hemodynamic Regulation of Tumor Necrosis Factor-{alpha} Gene and Protein Expression in Adult Feline Myocardium. Circ. Res. 81: 187-195 [Abstract] [Full Text]  
• Limas, C. J. (1997). Cardiac Autoantibodies in Dilated Cardiomyopathy : A Pathogenetic Role?. Circulation 95: 1979-1980 [Full Text]  
• Funaya, H., Kitakaze, M., Node, K., Minamino, T., Komamura, K., Hori, M. (1997). Plasma Adenosine Levels Increase in Patients With Chronic Heart Failure. Circulation 95: 1363-1365 [Abstract] [Full Text]  
• Kelly, R. A., Smith, T. W. (1997). Cytokines and Cardiac Contractile Function. Circulation 95: 778-781 [Full Text]  
• Wang, W. Z., Matsumori, A., Yamada, T., Shioi, T., Okada, I., Matsui, S., Sato, Y., Suzuki, H., Shiota, K., Sasayama, S. (1997). Beneficial Effects of Amlodipine in a Murine Model of Congestive Heart Failure Induced by Viral Myocarditis: A Possible Mechanism Through Inhibition of Nitric Oxide Production. Circulation 95: 245-251 [Abstract] [Full Text]  
• Torre-Amione, G., Kapadia, S., Lee, J., Durand, J.-B., Bies, R. D., Young, J. B., Mann, D. L. (1996). Tumor Necrosis Factor-{alpha} and Tumor Necrosis Factor Receptors in the Failing Human Heart. Circulation 93: 704-711 [Abstract] [Full Text]