Myocardial beta adrenoceptors and left ventricular function in hypertrophic cardiomyopathy.

L. Choudhury, S. Guzzetti, D. C. Lefroy, P. Nihoyannopoulos, W. J. McKenna, C. M. Oakley, P. G. Camici

MRC Clinical Sciences Centre, Hammersmith Hospital, London.

OBJECTIVE--To assess the relation between left ventricular function and myocardial beta adrenoceptor density. METHODS--17 patients with hypertrophic cardiomyopathy, six with and 11 without heart failure, were studied. Left ventricular function was assessed by echocardiography, and myocardial beta adrenoceptors by positron emission tomography. Patient data were compared with those obtained in normal controls. RESULTS--Myocardial beta adrenoceptor density in the 17 patients was 7.00 (SD 1.90) pmol/g v 11.50 (2.18) pmol/g in normal controls (P < 0.01). beta Adrenoceptor density in the six patients with left ventricular failure was 5.61 (0.88) pmol/g v 7.71 (1.86) pmol/g in the 11 patients with normal ventricular function (P < 0.05), and there was a significant correlation (r = 0.52; P < 0.05) between left ventricular fractional shortening and myocardial beta adrenoceptor density. A positive correlation (r = 0.51; P < 0.05) was also found between myocardial beta adrenoceptor density and the E/A transmitral flow ratio, an index of left ventricular diastolic function. CONCLUSIONS--There is myocardial beta adrenoceptor downregulation in patients with hypertrophic cardiomyopathy with or without signs of heart failure.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Nagueh, S. F., Mahmarian, J. J. (2006). Noninvasive Cardiac Imaging in Patients With Hypertrophic Cardiomyopathy. J Am Coll Cardiol 48: 2410-2422 [Abstract] [Full Text]  
• Olivotto, I., Cecchi, F., Gistri, R., Lorenzoni, R., Chiriatti, G., Girolami, F., Torricelli, F., Camici, P. G. (2006). Relevance of Coronary Microvascular Flow Impairment to Long-Term Remodeling and Systolic Dysfunction in Hypertrophic Cardiomyopathy. J Am Coll Cardiol 47: 1043-1048 [Abstract] [Full Text]  
• Camici, P G (2005). Coronary recanalisation, myocardial viability, and ventricular remodelling after infarction. Heart 91: 421-422 [Abstract] [Full Text]  
• Kies, P., Wichter, T., Schafers, M., Paul, M., Schafers, K. P., Eckardt, L., Stegger, L., Schulze-Bahr, E., Rimoldi, O., Breithardt, G., Schober, O., Camici, P. G. (2004). Abnormal Myocardial Presynaptic Norepinephrine Recycling in Patients With Brugada Syndrome. Circulation 110: 3017-3022 [Abstract] [Full Text]  
• Spyrou, N., Rosen, S. D., Fath-Ordoubadi, F., Jagathesan, R., Foale, R., Kooner, J. S., Camici, P. G. (2002). Myocardial beta-adrenoceptor densityone month after acute myocardial infarctionpredicts left ventricular volumes at six months. J Am Coll Cardiol 40: 1216-1224 [Abstract] [Full Text]  
• Carrio, I. (2001). Cardiac Neurotransmission Imaging. JNM 42: 1062-1076 [Abstract] [Full Text]  
• Freeman, K., Colon-Rivera, C., Olsson, M. C., Moore, R. L., Weinberger, H. D., Grupp, I. L., Vikstrom, K. L., Iaccarino, G., Koch, W. J., Leinwand, L. A. (2001). Progression from hypertrophic to dilated cardiomyopathy in mice that express a mutant myosin transgene. Am. J. Physiol. Heart Circ. Physiol. 280: H151-H159 [Abstract] [Full Text]  
• Wichter, T., Schafers, M., Rhodes, C. G., Borggrefe, M., Lerch, H., Lammertsma, A. A., Hermansen, F., Schober, O., Breithardt, G., Camici, P. G. (2000). Abnormalities of Cardiac Sympathetic Innervation in Arrhythmogenic Right Ventricular Cardiomyopathy : Quantitative Assessment of Presynaptic Norepinephrine Reuptake and Postsynaptic {beta}-Adrenergic Receptor Density With Positron Emission Tomography. Circulation 101: 1552-1558 [Abstract] [Full Text]  
• Camici, P. G (2000). IMAGING TECHNIQUES: Positron emission tomography and myocardial imaging. Heart 83: 475-480 [Full Text]  
• Karemaker, J.M., Lie, K.I. (2000). Heart rate variability: a telltale of health or disease. Eur Heart J 21: 435-437  
• Schafers, M., Lerch, H., Wichter, T., Rhodes, C. G., Lammertsma, A. A., Borggrefe, M., Hermansen, F., Schober, O., Breithardt, G.u., Camici, P. G. (1998). Cardiac sympathetic innervation in patients with idiopathic right ventricular outflow tract tachycardia. J Am Coll Cardiol 32: 181-186 [Abstract] [Full Text]  
• Schafers, M., Dutka, D., Rhodes, C. G., Lammertsma, A. A., Hermansen, F., Schober, O., Camici, P. G. (1998). Myocardial Presynaptic and Postsynaptic Autonomic Dysfunction in Hypertrophic Cardiomyopathy. Circ. Res. 82: 57-62 [Abstract] [Full Text]