Increased serum concentrations of interleukin-1 beta in patients with coronary artery disease.

D. Hasdai, M. Scheinowitz, E. Leibovitz, S. Sclarovsky, M. Eldar, V. Barak

Department of Cardiology, Tel-Aviv University, Petah Tikva, Israel.

OBJECTIVE: To assess serum interleukin-1 beta (IL-1 beta) concentrations in patients with ischaemic heart disease, to characterise subgroups of patients with raised IL-1 beta concentrations, and to examine whether serum IL-1 beta concentrations correlate with non-specific indices of inflammation. DESIGN: Survey study of patients with ischaemic heart disease. SETTING: Cardiac catheterisation laboratory of a tertiary medical centre. PATIENTS: Consecutive patients with angina pectoris and patients recovering from uncomplicated acute myocardial infarction and undergoing elective coronary angiography. RESULTS: Mean(SD) serum IL-1 beta concentrations were higher (P < 0.001) in patients with angina and < 50% coronary artery stenosis (n = 11; 18.8(19.9) pg/ml), patients with angina > or = 50% stenosis (n = 23; 10.2(11.4) pg/ml), and patients 8(0.8) days post-infarction (n = 13; 4.4(5.8) pg/ml) than in 15 healthy, age-matched controls (0.3(0.5) pg/ml). Serum IL-1 beta concentrations did not correlate with total blood leucocyte counts (r = -0.07, P = NS), blood lymphocyte counts (r = -0.24, P = NS), and blood monocyte counts (r = -0.29, P = NS), or with fibrinogen (r = -0.16, P = NS) and C-reactive protein concentrations (9(10.5) mg/dl v 14.1(19) mg/dl for patients with undetectable and detectable concentrations, respectively, P = NS). CONCLUSION: Serum IL-1 beta concentrations are raised in patients with ischaemic heart disease, in particular in those with minimal coronary artery disease and angina. The precise role of IL-1 beta in coronary artery disease remains to be determined.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Frantz, S., Bauersachs, J., Ertl, G. (2009). Post-infarct remodelling: contribution of wound healing and inflammation. Cardiovasc Res 81: 474-481 [Abstract] [Full Text]  
• Suarez, E. C., Krishnan, R. R., Lewis, J. G. (2003). The Relation of Severity of Depressive Symptoms to Monocyte-Associated Proinflammatory Cytokines and Chemokines in Apparently Healthy Men. Psychosom. Med. 65: 362-368 [Abstract] [Full Text]  
• Signorelli, S. S., Mazzarino, M. C., Pino, L. D., Malaponte, G., Porto, C., Pennisi, G., Marchese, G., Costa, M. P., Digrandi, D., Celotta, G., Virgilio, V. (2003). High circulating levels of cytokines (IL-6 and TNFa), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test. Vasc Med 8: 15-19 [Abstract]  
• Han, S. N., Leka, L. S., Lichtenstein, A. H., Ausman, L. M., Schaefer, E. J., Meydani, S. N. (2002). Effect of hydrogenated and saturated, relative to polyunsaturated, fat on immune and inflammatory responses of adults with moderate hypercholesterolemia. J. Lipid Res. 43: 445-452 [Abstract] [Full Text]  
• Momiyama, Y., Hirano, R., Taniguchi, H., Nakamura, H., Ohsuzu, F. (2001). Effects of interleukin-1 gene polymorphisms on the development of coronary artery disease associated with Chlamydia pneumoniae infection. J Am Coll Cardiol 38: 712-717 [Abstract] [Full Text]  
• Ehara, S., Ueda, M., Naruko, T., Haze, K., Itoh, A., Otsuka, M., Komatsu, R., Matsuo, T., Itabe, H., Takano, T., Tsukamoto, Y., Yoshiyama, M., Takeuchi, K., Yoshikawa, J., Becker, A. E. (2001). Elevated Levels of Oxidized Low Density Lipoprotein Show a Positive Relationship With the Severity of Acute Coronary Syndromes. Circulation 103: 1955-1960 [Abstract] [Full Text]  
• Balbay, Y., Tikiz, H., Baptiste, R.J., Ayaz, S., Sasmaz, H., Korkmaz, S. (2001). Circulating Interleukin-1 Beta, Interleukin-6, Tumor Necrosis Factor-Alpha, and Soluble ICAM-1 in Patients with Chronic Stable Angina and Myocardial Infarction. ANGIOLOGY 52: 109-114 [Abstract]  
• Dewberry, R., Holden, H., Crossman, D., Francis, S. (2000). Interleukin-1 Receptor Antagonist Expression in Human Endothelial Cells and Atherosclerosis. Arterioscler. Thromb. Vasc. Bio. 20: 2394-2400 [Abstract] [Full Text]  
• Pinto, J. M.B, Boyden, P. A (1999). Electrical remodeling in ischemia and infarction. Cardiovasc Res 42: 284-297 [Abstract] [Full Text]  
• Francis, S. E., Camp, N. J., Dewberry, R. M., Gunn, J., Syrris, P., Carter, N. D., Jeffery, S., Kaski, J. C., Cumberland, D. C., Duff, G. W., Crossman, D. C. (1999). Interleukin-1 Receptor Antagonist Gene Polymorphism and Coronary Artery Disease. Circulation 99: 861-866 [Abstract] [Full Text]