Register for email alerts and news feeds:
This journal | BMJ Group
rss
Heart 1997;78:396-398; doi:10.1136/hrt.78.4.396
Copyright © 1997 BMJ Publishing Group Ltd & British Cardiovascular Society

Heart 1997;78:396-398 ( October )

An association between arterial pulse pressure and variation in the fibrillin-1 gene

J T Powell,a R J Turner,a A M Henney,b G J Miller,c S E Humphriesb

a Cardiovascular and Pulmonary Research Division, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, UK, b Division of Cardiovascular Genetics, Rayne Institute, UCL Medical School, London WC1, UK, c Wolfson Institute of Preventative Medicine, The Medical College of St Bartholomew's Hospital, Charterhouse Square, London EC1, UK

Correspondence to: Dr Powell.

Accepted for publication 24 June 1997

Objective---To investigate whether variation in the fibrillin-1 gene was associated with blood pressure in healthy middle aged men, as had been observed in patients with abdominal aortic aneurysm.
Design, setting, and patients---Middle aged men (n = 245), aged 50 to 61 years, were recruited from one of the nine general practices participating in the second Northwick Park heart study. Blood samples were obtained for the preparation of genomic DNA and analysis of plasma variables.
Main outcome measures---Systolic, diastolic, and pulse pressures; fibrillin-1 genotype characterised with a four allele variable tandem nucleotide repeat polymorphism in intron 28.
Results---In healthy middle aged men only three common genotypes were observed: 2-2 (frequency 54.1%), 2-3 (16%), and 2-4 (15%). The mean arterial systolic (and pulse) pressure varied according to fibrillin-1 genotype: 2-4 genotype, 126.3 (47.6) mm Hg; 2-2 genotype, 131.0 (51.3) mm Hg; and 2-3 genotype, 135.5 (54.2) mm Hg. The median pulse pressure was 50 mm Hg. Distribution of men around the median pulse pressure, according to genotype, showed a significant trend for patients of 2-4 genotype to have the lowest pulse pressures, those of 2-2 genotype to have intermediate pressures, and those of 2-3 genotype to have the highest pulse pressures (p = 0.003 for healthy men).
Conclusions---There appears to be a significant association between fibrillin-1 genotype and arterial pulse pressure in men aged 50 to 61 years.

Keywords: blood pressure;  fibrillin;  pulse pressure

© 1997 by Heart
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

This article has been cited by other articles:

  • De Backer, J, Nollen, G J, Devos, D, Pals, G, Coucke, P, Verstraete, K, van der Wall, E E, De Paepe, A, Mulder, B J M (2006). Variability of aortic stiffness is not associated with the fibrillin 1 genotype in patients with Marfan's syndrome.. Heart 92: 977-978 [Full Text]  
  • Yasmin, , Wilkinson, I. B., O'Shaughnessy, K. M., Lanne, T., De Basso, R., Powell, J. T. (2006). Influence of fibrillin-1 genotype on aortic stiffness in men: a note of caution. J. Appl. Physiol. 100: 1431-1432 [Abstract] [Full Text]  
  • Powell, J. T., Turner, R. J., Sian, M., Debasso, R., Lanne, T. (2005). Influence of fibrillin-1 genotype on the aortic stiffness in men. J. Appl. Physiol. 99: 1036-1040 [Abstract] [Full Text]  
  • Medley, T. L., Cole, T. J., Gatzka, C. D., Wang, W. Y.S., Dart, A. M., Kingwell, B. A. (2002). Fibrillin-1 Genotype Is Associated With Aortic Stiffness and Disease Severity in Patients With Coronary Artery Disease. Circulation 105: 810-815 [Abstract] [Full Text]  

This Article

Services
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with

Register for free content

The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Show me all >>