Heart 1997;78:505-508 ( November )

Preliminary report

Measuring serum aminoterminal type III procollagen peptide, 7S domain of type IV collagen, and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy Yukihito Sato,^a Kazuaki Kataoka,^a Akira Matsumori,^b Shigetake Sasayama,^b Tasuku Yamada,^a Haruyasu Ito,^a Yoshiki Takatsu^a

^a Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, Amagasaki, Hyogo, Japan, ^b Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan

Correspondence to: Dr Sato, Division of Cardiology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital, 1-1-1 Higashidaimotsu-cho, Amagasaki, Hyogo 660, Japan.

Accepted for publication 22 July 1997

ObjectiveTo identify new prognostic indicators in idiopathic dilated cardiomyopathy (DCM) and secondary cardiomyopathy.
Design and patientsSerum concentrations of aminoterminal propeptides of type III procollagen and the 7S domain of type IV collagen (7S collagen)which have recently been used as indicators of collagen matrix turnover in other diseasesand of cardiac troponin T were measured in 17 consecutive patients with DCM and in four patients with secondary cardiomyopathy (one associated with hyperthyroidism, two with chronic renal failure, one with amyloidosis), confirmed by endomyocardial biopsy. The correlation of these variables with short term prognosis was then assessed prospectively.
Results11 of the patients were positive for type III procollagen, 7S collagen, or troponin T even though their creatine kinase concentrations were within the normal range. These patients had a poor short term prognosis (p < 0.001).
ConclusionsWithin the DCM and secondary cardiomyopathy groups, there was a subgroup of patients with raised concentrations of serum collagen and troponin T, for whom short term prognosis was poor. Although it is unclear whether these serum peptide levels reflect ongoing myocyte degeneration and interstitial fibrosis, they may serve as useful new prognostic indicators for cardiomyopathy.

Keywords: troponin T;  collagen;  dilated cardiomyopathy

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© 1997 by Heart
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