Heart 1998;79:93-95 ( January )
Case report
Granulocyte colony stimulating factor in neutropenic patients
with infective endocarditis
Medical Department B, Division of
Cardiology, 2142 Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen,
Denmark
Correspondence to: Dr Borgbjerg.
Accepted for publication 4 June 1997
A well known complication in the treatment of infectious
endocarditis is development of neutropenia caused by treatment with antibiotics in high concentrations over long periods. Neutropenia often
necessitates discontinuation of antibiotic treatment. Three patients
with infectious endocarditis who developed neutropenia are reported.
The patients were treated with granulocyte colony stimulating factor
(G-CSF), a haematopoietic growth factor that stimulates neutrophils.
G-CSF induced an immediate increase in white blood cell count,
primarily neutrophils. G-CSF may be effective in ameliorating
neutropenia in patients who receive antibiotics for treatment of
infectious endocarditis.
© 1998 by Heart
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