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Heart 1998;79:493-496; doi:10.1136/hrt.79.5.493
Copyright © 1998 BMJ Publishing Group Ltd & British Cardiovascular Society

Heart 1998;79:493-496 ( May )

Circadian rhythm of the signal averaged electrocardiogram and its relation to heart rate variability in healthy subjects

M Nakagawa,a T Iwao,a S Ishida,a H Yonemochi,a T Fujino,a T Saikawa,b M Itoa

a Department of Laboratory Medicine, Oita Medical University, Hasama-machi 1-1, Oita 879-55, Japan, b First Department of Internal Medicine, Oita Medical University

Correspondence to: Dr Nakagawa.

Accepted for publication 23 December 1997

Objective---To examine the circadian variation in the signal averaged electrocardiogram (saECG) and heart rate variability and investigate their relations in healthy subjects.
Methods---24 hour ECGs were obtained with a three channel recorder using bipolar X, Y, and Z leads in 20 healthy subjects. The following variables were determined hourly: heart rate, filtered QRS (f-QRS) duration, low and high frequency components of heart rate variability (LF and HF), and the LF/HF ratio.
Results---Heart rate, f-QRS duration, HF, and the LF/HF ratio showed significant circadian rhythms, as determined by the single cosinor method. Heart rate and the LF/HF ratio increased during daytime, and f-QRS duration and HF increased at night. f-QRS duration was negatively correlated with heart rate (r = 0.95, p < 0.001) and the LF/HF ratio (r = 0.94, p < 0.001) and positively with HF (r = 0.93, p < 0.001).
Conclusions---f-QRS duration has a significant circadian rhythm in healthy subjects and is closely related to the circadian rhythm of autonomic tone.

Keywords: signal averaged ECG;  f-QRS duration;  circadian rhythm;  heart rate variability

© 1998 by Heart
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