Heart 1998;80:28-34 ( July )
Relation between the kinetics of thallium-201 in myocardial scintigraphy and myocardial metabolism in patients with acute myocardial infarction
a First Department of
Internal Medicine, Osaka City University Medical School, 1-5-7 Asahi-Machi, Abeno-Ku, Osaka 545, Japan, b Division of Nuclear Medicine, Osaka
City University Medical School
Correspondence to: Dr Yamagishi.
Accepted for publication 4 February 1998
Objective
To
investigate the relations between myocardial metabolism and the
kinetics of thallium-201 in myocardial scintigraphy.
Methods46 patients
within six weeks after the onset of acute myocardial infarction
underwent resting myocardial dual isotope, single acquisition, single
photon emission computed tomography (SPECT) using radioiodinated
15-iodophenyl 3-methyl pentadecaenoic acid (BMIPP) and thallium-201,
exercise thallium-201 SPECT, and positron emission tomography (PET)
using nitrogen-13 ammonia (NH3) and [F18]fluorodeoxyglucose (FDG) under fasting conditions. The left ventricle was divided into nine segments, and the severity of defects
was assessed visually.
ResultsIn the resting
SPECT, less BMIPP uptake than thallium-201 uptake was observed in all
of 40 segments with reverse redistribution of thallium-201, and in 21 of 88 segments with a fixed defect of thallium-201 (p < 0.0001); and
more FDG uptake than NH3 uptake (NH3-FDG
mismatch) was observed in 35 of 40 segments with reverse redistribution
and in 38 of 88 segments with fixed defect (p < 0.0001). Less BMIPP
uptake in the resting SPECT was observed in 49 of 54 segments with slow
stress redistribution in exercise SPECT, and in nine of 17 segments
with rapid stress redistribution (p < 0.0005); NH3-FDG
mismatch was observed in 42 of 54 segments with slow stress
redistribution and in five of 17 segments with rapid stress
redistribution (p < 0.0005).
ConclusionsThallium-201
myocardial scintigraphy provides information about not only myocardial
perfusion and viability but also about myocardial metabolism in
patients with acute myocardial infarction.
© 1998 by Heart
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
