Heart 1998;80:263-269 ( September )
Sustained left ventricular diastolic dysfunction after exercise in patients with dilated cardiomyopathy
The First Department
of Medicine, Osaka University School of Medicine, Osaka, Japan
Correspondence to: Dr Hideyuki Sato, The First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Accepted for publication 12 May 1998
Objective
To
investigate the recovery process of exercise induced diastolic
dysfunction in heart failure, using Doppler echocardiographic techniques.
Design and
patientsTransmitral flow velocity profiles
and standard non-invasive haemodynamic indices were obtained serially
over seven days after symptom limited bicycle exercise tests in 18 patients with dilated cardiomyopathy and eight normal subjects. In
three patients with cardiomyopathy we also measured the pulmonary
capillary wedge pressure for 24 hours after exercise.
ResultsThe intensity
of exercise, as assessed by respiratory gas analysis, was lower in
patients with dilated cardiomyopathy than in normal subjects.
Despite the higher exercise level, all haemodynamic variables returned
to baseline within one hour after exercise in normal subjects. In
contrast, patients with dilated cardiomyopathy showed a sustained
decrease in the peak early diastolic filling velocity and a sustained
increase in the deceleration time of early filling for 24 hours or more
after exercise. Because other haemodynamic variables recovered within
one hour after exercise even in patients with dilated cardiomyopathy,
the postexercise changes in ventricular filling were not explained by
changes in loading conditions.
ConclusionsExercise
induced diastolic left ventricular dysfunction of the failing heart
persists for 24 hours or more after exercise. The efficacy of exercise
training on a daily basis in dilated cardiomyopathy requires further evaluation.
© 1998 by Heart
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Conraads, V. M.A., De Maeyer, C., Beckers, P., Possemiers, N., Martin, M., Van Hoof, V., Vrints, C. J.
(2008). Exercise-induced biphasic increase in circulating NT-proBNP levels in patients with chronic heart failure. Eur J Heart Fail
10: 793-795
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
