Heart 1998;80:334-337 ( October )

von Willebrand factor, tissue plasminogen activator, and dehydroepiandrosterone sulphate predict cardiovascular death in a 10 year follow up of survivors of acute myocardial infarction

J-H Jansson,^a T K Nilsson,^b O Johnson^b

^a Department of Internal Medicine, Skellefteå Hospital, Sweden, ^b Departments of Clinical Chemistry and Internal Medicine, Umeå University Hospital, Sweden

Correspondence to: Dr O Johnson, Department of Medicine, University Hospital of Umeå, S 901 85 Umeå, Sweden.

Accepted for publication 23 March 1998

BackgroundHaemostasis plays a major part in the process initiating a myocardial infarction. The impact of haemostatic variables on long term prognosis is unknown.
ObjectiveTo evaluate von Willebrand factor (vWF), tissue plasminogen activator antigen (t-PA) and its activity before and after venous occlusion, plasminogen activator inhibitor (PAI-1), dehydroepiandrosterone sulphate (DHEAS), and established clinical risk factors as long term predictors for reinfarction and mortality.
Patients123 consecutive survivors of myocardial infarction followed up for 10 years.
DesignStudy entry took place between 1982 and 1983. Fifty seven patients died (54 of cardiovascular disease) during the mean observation time of 10 years.
ResultsCox's univariate regression analysis showed that cardiovascular mortality was significantly associated with age, hypertension, previous history of angina pectoris, DHEAS, mass concentration of t-PA, and vWF. These associations were significant for vWF and mass concentration of t-PA after adjusting for age and hypertension.
ConclusionsA low concentration of DHEAS and high levels of the endothelially derived haemostatic variables vWF and mass concentration of t-PA are predictors of cardiovascular mortality in survivors of myocardial infarction. This association is independent of established clinical risk factors for mass concentration of t-PA and vWF.

Keywords: myocardial infarction;  risk factors;  fibrinolysis;  tissue plasminogen activator;  plasminogen activator inhibitor;  von Willebrand factor;  dehydroepiandrosterone sulphate

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© 1998 by Heart
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