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Heart 1998;80:338-340; doi:10.1136/hrt.80.4.338
Copyright © 1998 BMJ Publishing Group Ltd & British Cardiovascular Society

Heart 1998;80:338-340 ( October )

Prevalence of factor V Leiden (APCR) and other inherited thrombophilias in young patients with myocardial infarction and normal coronary arteries

A Dacosta,a B Tardy-Poncet,b K Isaaz,a A Cerisier,a P Mismetti,c S Simitsidis,c J Reynaud,b B Tardy,c M Piot,b H Decousus,c D Guyotatb

a Department of Cardiology, North Hospital, 42000 Saint-Etienne, France, b Department of Haematology, North Hospital, c Department of Clinical Pharmacology, Bellevue Hospital, 42000 Saint-Etienne, France

Correspondence to: Correspondence to: Pr K Isaaz, Hôpital Nord, CHU de Saint Etienne, Saint-Etienne Cedex 03, France.

Accepted for publication 16 February 1998

Objective---To investigate the role of activated protein C resistance (APCR, factor V Leiden) in coronary artery thrombosis.
Methods---The prevalence of APCR and of congenital deficiencies of antithrombin III, protein C, protein S, plasminogen, and factor XII was investigated in adult patients under 45 years of age with acute myocardial infarction. The results were compared with those of a group of 53 age and sex matched control subjects.
Results---Among 75 patients under the age of 45 years who were admitted from November 1994 to April 1996 for acute myocardial infarction, 22 (29.3%) had normal coronary arteriography (group I) and 53 (70.7%) had significant coronary artery disease (group II). Inherited thrombophilia was more often found in group I (4/22, 18.2%) than in group II (4/53, 7.5%) but the difference was not significant (F test: p = 0.22). The prevalence of APCR was 9.1% (2/22) in group I, 3.8% (2/53) in group 2 (p  = 0.57), and 3.8% (2/53) in the normal control group (p = 0.57).
Conclusions---The prevalence of congenital thrombophilias, including APCR, does not seem to be increased in young patients with myocardial infarction and normal coronary angiograms, compared with young patients with coronary atherosclerosis and with normal control subjects. However, the statistical power of the study is too low to detect a significant difference and these results are published to allow a meta-analysis of this problem in the future.

Keywords: myocardial infarction;  factor V Leiden;  coagulation factors;  inherited thrombophilia

© 1998 by Heart
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