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Heart 1999;81:248-251; doi:10.1136/hrt.81.3.248
Copyright © 1999 BMJ Publishing Group Ltd & British Cardiovascular Society
Heart 1999;81:248-251 ( March )

Cytomegalovirus seropositivity and incident ischaemic heart disease in the Caerphilly prospective heart disease study

D P Strachan,a D Carrington,b M A Mendall,c B K Butland,a P M Sweetnam,d P C Elwoodd

a Department of Public Health Sciences, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK, b Department of Medical Microbiology, St George's Hospital Medical School, c Division of Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, d Medical Research Council Epidemiology Unit (South Wales), Llandough Hospital, Penarth, South Glamorgan CF64 2XW, UK

Correspondence to: Professor Strachan.email: d.strachan{at}sghms.ac.uk


Accepted for publication 19 November 1998

OBJECTIVE---To assess the role of cytomegalovirus (CMV) infection in primary ischaemic heart disease.
METHODS---Plasma specimens collected during 1979-83 from men in Caerphilly, south Wales, were analysed for IgG antibodies to CMV by enzyme linked immunosorbent assay and latex tests. Incident ischaemic heart disease events were ascertained after five and 10 years from death certificates, hospital records, and ECG changes; 195 incident ischaemic heart disease cases were compared with 216 controls of a similar age drawn from the rest of the cohort.
RESULTS---164 cases (84%) and 180 controls (83%) were seropositive for CMV. Optical density, an indicator of CMV antibody titre, was similar for cases and controls. Among controls, seropositivity was not associated with age, socioeconomic status currently or in childhood, smoking, height, body mass index, blood pressure, total cholesterol, fibrinogen, plasma viscosity, or leucocyte count. The unadjusted odds ratio relating CMV seropositivity to incident ischaemic heart disease was 1.06 (95% confidence interval 0.63 to 1.79) and was little changed (1.11, 0.63 to 1.97) after adjustment for age, smoking, body mass index, systolic blood pressure, total cholesterol, and socioeconomic status currently and in childhood.
CONCLUSIONS---CMV infection is unlikely to be a strong risk factor for development of myocardial infarction in middle aged men.


Keywords: cytomegalovirus; coronary artery disease; atherosclerosis

© 1999 by Heart
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