Heart 1999;81:276-277 ( March )

Pregnancy after atrial repair for transposition of the great arteries

M Genoni,^a R Jenni,^b S P Hoerstrup,^a P Vogt,^a M Turina^a

^a Clinic for Cardiovascular Surgery, University Hospital, Zurich, Switzerland, ^b Division of Echocardiography, University Hospital

Correspondence to: Dr Michele Genoni, Klinik für Herzchirurgie, Universitätsspital, CH-8091 Zürich, Switzerland.

Accepted for publication 13 July 1998

OBJECTIVETo investigate the risk of pregnancy in patients with transposition of the great arteries (TGA) who have undergone atrial repair.
DESIGNRetrospective analysis (1962-94) of 342 TGA patients who underwent atrial repair. Of 231 known late survivors, 48 were women over 18 years old who were interviewed about possible reproductive plans and previous pregnancies. As a control, comparison was made with data of 57 500 women (mean age 26 years) obtained from the Swiss Statistical Bank in Bern.
RESULTSMean follow up was 13.7 years; 66% remained asymptomatic, 29% had mild to moderate cardiac symptoms, and 5% suffered from severe cardiac symptoms (New York Heart Association grade III-IV). Thirty six of the 48 women wished to bear children and, to date, there have been 10 live births, two spontaneous first trimester abortions, and one induced abortion at 16 weeks. During pregnancy there was one case of cardiac deterioration and two cases of pneumonia. There was no evidence of congenital heart disease in the children.
CONCLUSIONSIn this relatively small series the completion of pregnancy in women with TGA who had undergone atrial repair and who had normal functional cardiac status was uncomplicated

Keywords: congenital heart disease; pregnancy; transposition of the great arteries; atrial repair

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© 1999 by Heart
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