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Heart 1999;81:278-284; doi:10.1136/hrt.81.3.278
Copyright © 1999 BMJ Publishing Group Ltd & British Cardiovascular Society
Heart 1999;81:278-284 ( March )

Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy

M Mundhenke, B Schwartzkopff, M Köstering, U Deska, R M Klein, B E Strauer

Division of Cardiology, Pneumology and Angiology, School of Medicine, Heinrich Heine University, Moorenstrabeta e 5, 40225 Düsseldorf, Germany

Correspondence to: Dr Schwartzkopff. email: schwartk{at}uni-duesseldorf.de


Accepted for publication 26 October 1998

OBJECTIVE---To determine whether increased plasma concentrations of endothelin-1 (ET-1) and big endothelin (BET) play a role in the regulation of coronary circulation in patients with idiopathic dilated cardiomyopathy (IDCM).
SETTING---Tertiary referral centre for cardiac diseases.
PATIENTS---Fourteen patients (eight male/six female; mean (SD) age 59 (9) years) with IDCM (ejection fraction 36 (9)%) and five normotensive subjects (two male/three female; age 52 (7) years) serving as controls were studied.
METHODS---Functional status was classified according to New York Heart Association (NYHA) class. Endogenous ET-1 and BET plasma concentrations from the aorta and the coronary sinus were determined by radioimmunoassay. Coronary blood flow, using the inert chromatographic argon method, myocardial oxygen consumption, and coronary sinus oxygen content under basal conditions were determined.
RESULTS---In the aorta, mean (SD) concentrations of ET-1 (IDCM 0.76 (0.25) v controls 0.31 (0.06) fmol/ml; p = 0.002) and BET (IDCM 3.58 (1.06) v controls 2.11 (0.58) fmol/ml; p = 0.014) were increased in patients with IDCM. Aortic ET-1 concentrations correlated positively with NYHA class (r = 0.731; p < 0.001), myocardial oxygen consumption (r = 0.749; p < 0.001), and coronary blood flow (r = 0.645; p = 0.003), but inversely with coronary sinus oxygen content (r = -0.633; p = 0.004), which was significantly decreased in IDCM patients (IDCM 4.68 (1.05) v controls 6.70 (1.06) vol%; p = 0.003).
CONCLUSIONS---The coronary circulation in patients with IDCM is exposed to an increased endothelin load. ET-1 concentrations correlate with functional deterioration. A decrease of the coronary sinus content of oxygen suggests a mismatch between coronary blood flow and metabolic demand. Thus, ET-1 might be a marker of a disequilibrium between myocardial oxygen demand and coronary blood flow in IDCM.

Keywords: endothelin; dilated cardiomyopathy; coronary circulation; myocardial oxygen consumption

© 1999 by Heart
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