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Heart 1999;81:501-504; doi:10.1136/hrt.81.5.501
Copyright © 1999 BMJ Publishing Group Ltd & British Cardiovascular Society
Heart 1999;81:501-504 ( May )

Abnormalities of vascular endothelial function may contribute to increased coronary heart disease risk in UK Indian Asians

J C Chambers,a A McGregor,b J Jean-Marie,b J S Koonera

a National Heart and Lung Institute, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK, b Department of Cardiology, Ealing Hospital, Middlesex, UK

Correspondence to: Dr Kooner. email: jkooner{at}rpms.ac.uk

Accepted for publication 25 November 1998

OBJECTIVE---To test the hypothesis that abnormalities of endothelial function are present in Indian Asians and may contribute to their increased coronary heart disease risk.
SETTING---Single centre in west London.
PATIENTS---26 Indian Asian and 18 European white healthy male subjects, aged 35 to 61 years recruited from general practice lists.
DESIGN---Brachial artery diameter responses to reactive hyperaemia and sublingual glyceryl trinitrate were compared using high resolution ultrasound.
RESULTS---Mean (SEM) flow mediated, endothelium dependent dilatation was reduced in Indian Asians compared with European whites, at 3.2 (0.8)% v 5.9 (1.0)%, p = 0.03. In contrast, there were no significant differences in baseline brachial arterial diameter (4.6 (0.1) v 4.6 (0.1) mm, p = 0.65) or glyceryl trinitrate induced dilatation (18.8 (1.5)% v 18.5 (1.7)%, p = 0.90) between Indian Asians and European whites, respectively. Univariate analysis showed that Indian Asian race was significantly associated with impaired flow mediated dilatation (regression coefficient = -2.8 (1.3)%, p = 0.03), and in multivariate analysis, this relation was independent of both conventional coronary heart disease risk factors and markers of insulin resistance.
CONCLUSIONS---Endothelial function is impaired in healthy UK Indian Asians compared with European whites, and the defect is not accounted for by major coronary heart disease risk factors. Endothelial function may be modulated by novel risk factors in Indian Asians.


Keywords: endothelial function; Indian Asians; coronary heart disease; risk factors

© 1999 by Heart
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