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Heart 1999;82:15-18; doi:10.1136/hrt.82.1.15
Copyright © 1999 BMJ Publishing Group Ltd & British Cardiovascular Society
Heart 1999;82:15-18 ( July )

QT dispersion is reduced after valve replacement in patients with aortic stenosis

D Darbar, C J Cherry, D M Kerins

Department of Medicine, Vanderbilt University and Veterans Administration Medical Center, Nashville, Tennessee, USA

Correspondence to: Dr David M Kerins, Division of Cardiology, Medical Research Building-II, Room 315, Vanderbilt University, Nashville, TN 37232-6300, USA. email: david.kerins{at}mcmail.vanderbilt.edu

Accepted for publication 22 December 1998

OBJECTIVE---To investigate whether QT dispersion is a reliable index of the severity of aortic stenosis and left ventricular hypertrophy in the setting of aortic stenosis.
DESIGN---A retrospective analysis of the results of echocardiography and electrocardiography before and after aortic valve replacement.
SETTING---Tertiary centre.
PATIENTS---36 men (30 white and six black) with symptomatic aortic stenosis requiring valve replacement.
RESULTS---All patients had significant aortic stenosis (mean (SD) aortic valve area 0.68 (0.18) cm2) and evidence of left ventricular hypertrophy (left ventricular mass index (LVMI): 267 (90) g/m2). Before aortic valve replacement, QT dispersion was correlated with mean aortic valve area and LVMI (r = 0.697, p < 0.001, and r = 0.59, p < 2.4 × 10-6, respectively). QT dispersion and QT corrected for heart rate dispersion decreased from 133 (54) to 71 (33) ms and from 151 (64) to 94 (76) ms, respectively (p < 0.001 for both). LVMI regressed after aortic valve replacement to 190 (79) g/m2, p < 0.01.
CONCLUSIONS---QT dispersion is increased in association with LVMI in patients with significant symptomatic aortic stenosis. Aortic valve replacement reduces QT dispersion and LVMI. QT dispersion could be a useful indicator of risk and risk reduction in patients with significant symptomatic aortic stenosis.


Keywords: QT dispersion; left ventricular hypertrophy; aortic valve replacement

© 1999 by Heart
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