Heart 1999;82:226-233 ( August )

Clinical outcomes of acute myocarditis in childhood

K J Lee^a, B W McCrindle^a, D J Bohn^b, G J Wilson^c, G P Taylor^c, R M Freedom^a, J F Smallhorn^a, L N Benson^a

^a Division of Cardiology, Hospital for Sick Children, 555 University Avenue,Toronto, Ontario M5G 1X8, Canada, ^b Department of Critical Care Medicine, Hospital for Sick Children, ^c Department of Laboratory Medicine, Hospital for Sick Children

Correspondence to: Dr Benson. email: benson{at}sickkids.on.ca

Accepted for publication 3 February 1999

OBJECTIVETo describe clinical outcomes of a paediatric population with histologically confirmed lymphocytic myocarditis.
DESIGNA retrospective review between November 1984 and February 1998.
SETTINGA major paediatric tertiary care hospital.
PATIENTS36 patients with histologically confirmed lymphocytic myocarditis.
MAIN OUTCOME MEASURESSurvival, cardiac transplantation, recovery of ventricular function, and persistence of dysrhythmias.
RESULTSFreedom from death or cardiac transplantation was 86% at one month and 79% after two years. Five deaths occurred within 72 hours of admission, and one late death at 1.9 years. Extracorporeal membrane oxygenation support was used in four patients, and three patients underwent heart replacement. 34 patients were treated with intravenous corticosteroids. In the survivor/non-cardiac transplantation group (n = 29), the median follow up was 19 months (range 1.2-131.6 months), and the median period for recovery of a left ventricular ejection fraction to > 55% was 2.8 months (range 0-28 months). The mean (SD) final left ventricular ejection and shortening fractions were 66 (9)% and 34 (8)%, respectively. Two patients had residual ventricular dysfunction. No patient required antiarrhythmic treatment. All survivors reported no cardiac symptoms or restrictions in physical activity.
CONCLUSIONSOur experience documents good outcomes in paediatric patients presenting with acute heart failure secondary to acute lymphocytic myocarditis treated with immunosuppression. Excellent survival and recovery of ventricular function, with the absence of significant arrhythmias, continued cardiac medications, or restrictions in physical activity were the normal outcomes.


Keywords: myocarditis; paediatric cardiology; immunosuppression

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© 1999 by Heart
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