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Department of
Cardiology, Jichi Medical School, Minamikawachi-machi, Tochigi
329-0498, Japan
Correspondence to: Dr Hojo email: yhojo{at}jichi.ac.jp
Accepted 8 November
1999
OBJECTIVE
To investigate the clinical significance of
circulating hepatocyte growth factor (HGF) and the role of peripheral
blood mononuclear cells (monocytes), which are a possible source of
HGF, in patients with acute myocardial infarction.
DESIGN AND PATIENTS37 patients with acute myocardial
infarction and 13 normal control subjects were recruited. Peripheral
venous blood samples were drawn from the infarct patients 1, 7, 14, and
21 days after onset. Monocytes were isolated from peripheral blood at
those times. HGF concentrations in serum and in a culture medium of monocytes after incubation for 24 hours (monocyte HGF levels) were
measured by enzyme linked immunosorbent assay.
RESULTSSerum HGF and monocyte HGF values within seven
days after onset of myocardial infarction were significantly higher
than those of control subjects and decreased by day 14. There were
significant positive correlations between serum HGF and monocyte HGF
levels on day 7; between maximum plasma creatine phosphokinase levels and serum HGF levels on day 1; between maximum plasma C reactive protein and serum HGF levels; and between maximum C reactive protein and monocyte HGF levels. Monocyte HGF levels were raised in the patients with progression of ventricular enlargement in the course of
acute myocardial infarction.
CONCLUSIONSEarly serum HGF concentrations reflect the
extent of myocardial damage in acute myocardial infarction patients.
Inflammation after acute myocardial infarction is supposed to be
involved in enhanced HGF production. Monocytes may play an important
role in ventricular remodelling after acute myocardial infarction by releasing the cardiovascular protective mitogen HGF.
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