Heart 2000;84:183-188 ( August )

Cardiovascular medicine

Double blind randomised placebo controlled trial of adjunctive prednisolone in the treatment of effusive tuberculous pericarditis in HIV seropositive patients J G Hakim^a, I Ternouth^a, E Mushangi^a, S Siziya^b, V Robertson^c, A Malin^d

^a Department of Medicine, University of Zimbabwe, PO Box A 178, Avondale, Harare, Zimbabwe, ^b Department of Community Medicine, University of Zimbabwe, ^c Department of Medical Microbiology, University of Zimbabwe, ^d Department of Respiratory Medicine, Royal United Hospital, Combe Park, Bath BA1 3NG, UK

Correspondence to: Dr Hakim email: jhakim{at}healthnet.zw

Accepted 5 April 2000

OBJECTIVETo determine the effect of adjunctive prednisolone on morbidity, pericardial fluid resolution, and mortality in HIV seropositive patients with effusive tuberculous pericarditis.
DESIGNDouble blind randomised placebo controlled trial.
SETTINGTwo medical school affiliated referral hospitals in Harare, Zimbabwe.
PATIENTS58 HIV seropositive patients aged 18-55 years with tuberculous pericarditis.
INTERVENTIONSAll patients received standard short course antituberculous chemotherapy and were randomly assigned to receive prednisolone or placebo for six weeks.
MAIN OUTCOME MEASURESClinical improvement, echocardiographic and radiologic pericardial fluid resolution, and death.
RESULTS29 patients were assigned to prednisolone and 29 to placebo. After 18 months of follow up there were five deaths in the prednisolone treated group and 10 deaths in the placebo group. Mortality was significantly lower in the prednisolone group (log rank ² = 8.19, df = 1, p = 0.004). Resolution of raised jugular venous pressure (p = 0.017), hepatomegaly (p = 0.007), and ascites (p = 0.015), and improvement in physical activity (p = 0.02), were significantly more rapid in the prednisolone treated patients. However, there was no difference in the rate of radiologic and echocardiographic resolution of pericardial effusion.
CONCLUSIONSAdjunctive prednisolone for effusive tuberculous pericarditis produced a pronounced reduction in mortality. It is suggested prednisolone should be added to standard short course chemotherapy to treat HIV related effusive tuberculous pericarditis.


Keywords: tuberculous pericarditis; HIV infection; echocardiography; prednisolone

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© 2000 by Heart
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