Heart 2001;85:635-638 ( June )

Cardiovascular medicine

The vitamin D receptor genotype predisposes to the development of calcific aortic valve stenosis J R Ortlepp, R Hoffmann, F Ohme, J Lauscher, F Bleckmann, P Hanrath

Medical Clinic I, University Hospital of Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany

Correspondence to: Dr Ortlepp jort{at}pcserver.mk1.rwth-aachen.de

Accepted 8 November 2000

OBJECTIVETo test the hypothesis that vitamin D receptor polymorphism is associated with calcific aortic valve stenosis.
DESIGNThe distribution of one polymorphism of the vitamin D receptor (BsmI B/b) was examined in 100 consecutive patients with calcific valvar aortic stenosis and compared with a control group of 100 patients (paired match for age, sex, and the presence of coronary artery disease from a total of 630 patients without calcified aortic valves). Polymerase chain reaction and restriction fragment length polymorphism were used to determine genotypes.
RESULTSThere was a significant difference in vitamin D receptor allele and genotype frequencies between the two groups. The allele B had a higher prevalence in patients with calcific aortic stenosis (B = 0.56, b = 0.44) than in the control cohort (B = 0.40, b = 0.60) (p = 0.001).
CONCLUSIONSThere is a significant association of vitamin D receptor polymorphism with calcific aortic valve stenosis. The B allele of the vitamin D receptor is more common in patients with calcific aortic valve stenosis. It now needs to be evaluated whether other genes that control calcium homeostasis are involved in the pathogenesis of this disorder.


Keywords: vitamin D receptor; calcific aortic stenosis; aortic valve; genetic polymorphism

---

© 2001 by Heart
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Ngo, D. T.M., Sverdlov, A. L., Willoughby, S. R., Nightingale, A. K., Chirkov, Y. Y., McNeil, J. J., Horowitz, J. D. (2009). Determinants of Occurrence of Aortic Sclerosis in an Aging Population. J Am Coll Cardiol Img 2: 919-927 [Abstract] [Full Text]  
• Barrick, C. J., Roberts, R. B., Rojas, M., Rajamannan, N. M., Suitt, C. B., O'Brien, K. D., Smyth, S. S., Threadgill, D. W. (2009). Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice. Am. J. Physiol. Heart Circ. Physiol. 297: H65-H75 [Abstract] [Full Text]  
• Akat, K, Borggrefe, M, Kaden, J J (2009). Aortic valve calcification: basic science to clinical practice. Heart 95: 616-623 [Abstract] [Full Text]  
• Parolari, A., Loardi, C., Mussoni, L., Cavallotti, L., Camera, M., Biglioli, P., Tremoli, E., Alamanni, F. (2009). Nonrheumatic calcific aortic stenosis: an overview from basic science to pharmacological prevention. Eur. J. Cardiothorac. Surg. 35: 493-504 [Abstract] [Full Text]  
• Rajamannan, N. M. (2009). Calcific Aortic Stenosis: Lessons Learned From Experimental and Clinical Studies. Arterioscler. Thromb. Vasc. Bio. 29: 162-168 [Abstract] [Full Text]  
• Shuvy, M., Abedat, S., Beeri, R., Danenberg, H. D., Planer, D., Ben-Dov, I. Z., Meir, K., Sosna, J., Lotan, C. (2008). Uraemic hyperparathyroidism causes a reversible inflammatory process of aortic valve calcification in rats. Cardiovasc Res 79: 492-499 [Abstract] [Full Text]  
• Bosse, Y., Mathieu, P., Pibarot, P. (2008). Genomics: The Next Step to Elucidate the Etiology of Calcific Aortic Valve Stenosis. J Am Coll Cardiol 51: 1327-1336 [Abstract] [Full Text]  
• Stone, P. H. (2007). C-Reactive Protein to Identify Early Risk for Development of Calcific Aortic Stenosis: Right Marker? Wrong Time?. J Am Coll Cardiol 50: 1999-2001 [Full Text]  
• Ertas, F. S., Hasan, T., Ozdol, C., Gulec, S., Atmaca, Y., Tulunay, C., Karabulut, H., Kocum, H. T., Dincer, I., Kose, K. S., Erol, C. (2007). Relationship Between Angiotensin-Converting Enzyme Gene Polymorphism and Severity of Aortic Valve Calcification. Mayo Clin Proc. 82: 944-948 [Abstract] [Full Text]  
• Bella, J. N., Tang, W., Kraja, A., Rao, D. C., Hunt, S. C., Miller, M. B., Palmieri, V., Roman, M. J., Kitzman, D. W., Oberman, A., Devereux, R. B., Arnett, D. K. (2007). Genome-Wide Linkage Mapping for Valve Calcification Susceptibility Loci in Hypertensive Sibships: The Hypertension Genetic Epidemiology Network Study. Hypertension 49: 453-460 [Abstract] [Full Text]  
• Griffin, B. P. (2007). Statins in Aortic Stenosis: New Data From a Prospective Clinical Trial. J Am Coll Cardiol 49: 562-564 [Full Text]  
• O'Brien, K. D. (2006). Pathogenesis of Calcific Aortic Valve Disease: A Disease Process Comes of Age (and a Good Deal More). Arterioscler. Thromb. Vasc. Bio. 26: 1721-1728 [Abstract] [Full Text]  
• Liebe, V., Brueckmann, M., Borggrefe, M., Kaden, J. J. (2006). Statin therapy of calcific aortic stenosis: hype or hope?. Eur Heart J 27: 773-778 [Abstract] [Full Text]  
• Probst, V., Le Scouarnec, S., Legendre, A., Jousseaume, V., Jaafar, P., Nguyen, J.-M., Chaventre, A., Le Marec, H., Schott, J.-J. (2006). Familial Aggregation of Calcific Aortic Valve Stenosis in the Western Part of France. Circulation 113: 856-860 [Abstract] [Full Text]  
• Freeman, R. V., Otto, C. M. (2005). Spectrum of Calcific Aortic Valve Disease: Pathogenesis, Disease Progression, and Treatment Strategies. Circulation 111: 3316-3326 [Full Text]  
• O'Brien, K. D., Probstfield, J. L., Caulfield, M. T., Nasir, K., Takasu, J., Shavelle, D. M., Wu, A. H., Zhao, X.-Q., Budoff, M. J. (2005). Angiotensin-Converting Enzyme Inhibitors and Change in Aortic Valve Calcium. Arch Intern Med 165: 858-862 [Abstract] [Full Text]  
• (2005). Systolic murmur in an asymptomatic 70 year old man. Heart 91: 125-125 [Full Text]  
• Novaro, G. M. (2004). Electron Beam Computed Tomography: The Latest "Stethoscope" for Calcific Aortic Valve Disease. Mayo Clin Proc. 79: 1239-1241  
• Gibbons, G. H., Liew, C. C., Goodarzi, M. O., Rotter, J. I., Hsueh, W. A., Siragy, H. M., Pratt, R., Dzau, V. J. (2004). Genetic Markers: Progress and Potential for Cardiovascular Disease. Circulation 109: IV-47-IV-58 [Full Text]  
• Otto, C. M. (2004). Why is aortic sclerosis associated with adverse clinical outcomes?. J Am Coll Cardiol 43: 176-178 [Full Text]  
• Novaro, G. M., Sachar, R., Pearce, G. L., Sprecher, D. L., Griffin, B. P. (2003). Association Between Apolipoprotein E Alleles and Calcific Valvular Heart Disease. Circulation 108: 1804-1808 [Abstract] [Full Text]  
• Ortlepp, J R, Schmitz, F, Bozoglu, T, Hanrath, P, Hoffmann, R (2003). Cardiovascular risk factors in patients with aortic stenosis predict prevalence of coronary artery disease but not of aortic stenosis: an angiographic pair matched case-control study. Heart 89: 1019-1022 [Abstract] [Full Text]  
• Chan, K.-L. (2003). Is aortic stenosis a preventable disease?. J Am Coll Cardiol 42: 593-599 [Abstract] [Full Text]  
• Drolet, M.-C., Arsenault, M., Couet, J. (2003). Experimental aortic valve stenosis in rabbits. J Am Coll Cardiol 41: 1211-1217 [Abstract] [Full Text]  
• Peacock, M., Turner, C. H., Econs, M. J., Foroud, T. (2002). Genetics of Osteoporosis. Endocr. Rev. 23: 303-326 [Abstract] [Full Text]  
• OTTO, C. M, O'BRIEN, K. D (2001). Why is there discordance between calcific aortic stenosis and coronary artery disease?. Heart 85: 601-602 [Full Text]