Electronic pages: case reports
Long
term inhalation of iloprost in a child with primary pulmonary
hypertension: an alternative to continuous infusion
M Beghettia, M Bernerb, P C Rimensbergerb
a Cardiology
Unit, Hôpital des Enfants, Department of Paediatrics, University
Hospital of Geneva, 1211 Genève 14, Switzerland, b Neonatology and Intensive Care Division,
Hôpital des Enfants
Correspondence to: Dr Beghetti maurice.beghetti{at}hcuge.ch
Accepted 25 May 2001
Primary pulmonary hypertension is a rare disease in childhood
associated with a poor prognosis. However, during the past 10 years,
pulmonary vasodilator treatment has somewhat improved its prognosis.
Long term continuous infusion of prostacyclin (epoprostenol) has been
shown to improve physical capacity and to reduce mortality in primary
and secondary pulmonary hypertension. It has been reported in adults
that daily repetitive inhalation of iloprost, a prostacyclin analogue,
seems also suitable for long term therapy of pulmonary hypertension.
Repetitive inhalation of iloprost was administered to a 5 year old boy
with severe primary pulmonary hypertension. He showed continuous
clinical improvement without any side effects over the three years of
treatment. This treatment may offer an alternative to continuous
intravenous prostacyclin infusion and obviates the need for a permanent
central venous catheter.
Keywords: iloprost; inhalation; prostacyclin; pulmonary hypertension
© 2001 by Heart
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Baker, S. E, Hockman, R. H.
(2005). Inhaled Iloprost in Pulmonary Arterial Hypertension. The Annals of Pharmacotherapy
39: 1265-1274
[Abstract] [Full Text] -
Tissieres, P., Nicod, L., Barazzone-Argiroffo, C., Rimensberger, P. C., Beghetti, M.
(2004). Aerosolized iloprost as a bridge to lung transplantation in a patient with cystic fibrosis and pulmonary hypertension. Ann. Thorac. Surg.
78: e48-e50
[Abstract] [Full Text] -
Emmel, M, Keuth, B, Schickendantz, S
(2004). Paradoxical increase of pulmonary vascular resistance during testing of inhaled iloprost. Heart
90: e2-2
[Abstract] [Full Text] -
Olschewski, H., Simonneau, G., Galie, N., Higenbottam, T., Naeije, R., Rubin, L. J., Nikkho, S., Speich, R., Hoeper, M. M., Behr, J., Winkler, J., Sitbon, O., Popov, W., Ghofrani, H. A., Manes, A., Kiely, D. G., Ewert, R., Meyer, A., Corris, P. A., Delcroix, M., Gomez-Sanchez, M., Siedentop, H., Seeger, W., the Aerosolized Iloprost Randomized Study Group,
(2002). Inhaled Iloprost for Severe Pulmonary Hypertension. NEJM
347: 322-329
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
