REVIEW

Inflammation in acute coronary syndromes

N T Mulvihill, J B Foley

Department of Cardiology, St James's Hospital, Dublin 8, Republic of Ireland

Correspondence to:
Correspondence to:
Dr N T Mulvihill, Unité de Cardiologie Interventionnelle, Clinique Pasteur, 45 Avenue de Lombez, 31076 Toulouse, France;
mulvihin{at}hotmail.com

Extensive evidence supports a pathogenic role for both local and systemic inflammation in acute coronary syndromes. However, several important questions remain unanswered. Is the observed inflammatory process a precursor or a consequence of coronary plaque rupture? Is the inflammatory component of unstable coronary disease a potential therapeutic target? Finally, do infectious agents have a pathogenic role in coronary atherosclerosis and acute coronary syndromes?

Keywords: acute coronary syndromes; atherosclerosis; inflammation; plaque

Abbreviations: CMV, cytomegalovirus; CRP, C reactive protein; ICAM-1, intercellular adhesion molecule-1; NF-B, nuclear factor B; VCAM-1, vascular cell adhesion molecule-1

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