VIEWPOINT

Nitric oxide and myocardial function in heart failure: friend or foe?

J M Cotton, M T Kearney, A M Shah

Department of Cardiology, Guy’s King’s & St Thomas’s School of Medicine, King’s College London (Denmark Hill Campus), London, UK

Correspondence to:
Correspondence to:
Professor Ajay M Shah, Department of Cardiology, Guy’s King’s & St Thomas’s School of Medicine, Bessemer Road, London SE5 9PJ, UK;
ajay.shah{at}kcl.ac.uk

There is good evidence that nitric oxide has important autocrine/paracrine effects in the myocardium, serving to optimise and fine tune cardiac function

Keywords: nitric oxide; heart failure; myocardial function

Abbreviations: DCM, dilated cardiomyopathy; NO, nitric oxide; NOS, NO synthase; eNOS, endothelial NOS; iNOS, inducible NOS; nNOS, neuronal NOS; SR, sarcoplasmic reticulum

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