REVIEW

Biochemical markers of myocyte injury in heart failure

Y Sato¹, T Kita¹, Y Takatsu², T Kimura¹

¹ Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
² Department of Cardiovascular Medicine, Amagasaki Hospital, Japan

Correspondence to:
Correspondence to:
Dr Y Sato
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; cardioys{at}kuhp.kyoto-u.ac.jp

This review discusses the role of biochemical markers of myocyte injury in patients with chronic congestive heart failure. Heart specific assays have been developed for the measurement of cardiac troponin T (cTnT), cardiac troponin I (cTnI), heart type fatty acid binding protein (H-FABP), and myosin light chain 1 (MLC-1). Concentrations of these biochemical markers increase in the absence of ischaemic events in the subset of patients with heart failure whose long term outcomes are most adverse. The markers are easy to measure serially and it is therefore easy to follow patients without inter-observer variability. The serial clinical use of these markers, separately or in combination, will sharpen our understanding of the state of heart failure.

Abbreviations: BNP, brain natriuretic peptide; cTnI, cardiac troponin I; cTnT, cardiac troponin T; CK, creatine kinase; DCM, dilated cardiomyopathy; H-FABP, heart type fatty acid binding protein; MB, myocardial band; MLC-1, myosin light chain 1; NYHA, New York Heart Association

Keywords: heart failure; troponin; heart type fatty acid binding protein; myosin light chain 1; brain natriuretic peptide

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