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Heart 2004;90:827-828; doi:10.1136/hrt.2003.030379
Copyright © 2004 BMJ Publishing Group Ltd & British Cardiovascular Society
Heart 2004;90:827-828
© 2004 by BMJ Publishing Group & British Cardiac Society

EDITORIAL

Will oral antithrombin agents replace warfarin?

P R Sinnaeve and F J Van de Werf

Department of Cardiology, University of Leuven, Leuven, Belgium

Correspondence to:
Correspondence to:
F J Van de Werf MD PhD
Department of Cardiology, Gasthuisberg University Hospital, Herestraat 49, B-3000 Leuven, Belgium; frans.vandewerf{at}uz.kuleuven.ac.be

ABSTRACT

The new oral direct thrombin inhibitor ximelagatran is at least equivalent to warfarin for stroke prevention in patients with non-valvar atrial fibrillation, and seems to be a promising adjunct to aspirin after acute coronary syndrome

Abbreviations: ACS, acute coronary syndrome; AF, atrial fibrillation; DTI, direct thrombin inhibitor; ESTEEM, efficacy and safety of the oral direct thrombin inhibitor ximelagatran in patients with recent myocardial damage; INR, international normalised ratio; NSTEMI, non-ST elevated myocardial infarction; SPORTIF, stroke prevention using an oral thrombin inhibitor in patients with atrial fibrillation

Keywords: oral antithrombin agents; warfarin; thrombosis; ximelagatran


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