REVIEW
Clopidogrel in non-ST segment elevation acute coronary syndromes: an overview of the submission by the British Cardiac Society and the Royal College of Physicians of London to the National Institute for Clinical Excellence, and beyond
1 Regional Medical Cardiology Centre, Royal Victoria Hospital, Belfast, UK
2 Cardiovascular Research Unit, University of Sheffield, Northern General Hospital, Sheffield, UK
Correspondence to:
Correspondence to:
Professor A A Jennifer Adgey
Regional Medical Cardiology Centre, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, UK; jennifer.adgey{at}royalhospitals.n-i.nhs.uk
A comprehensive appraisal was undertaken on behalf of the British Cardiac Society and the Royal College of Physicians of London to assess the use of clopidogrel in acute coronary syndromes. The appraisal was submitted to the National Institute for Clinical Excellence (NICE) in August 2003 and contributed to the development of the recently published guidelines for the use of clopidogrel in acute coronary syndromes. The submission to NICE and more recent publications evaluating the use of clopidogrel are reviewed.
Abbreviations: ACS, acute coronary syndromes; CABG, coronary artery bypass graft; CAPRIE, clopidogrel versus aspirin in patients at risk of ischaemic events; CI, confidence interval; CREDO, clopidogrel for the reduction of events during observation; CURE, clopidogrel in unstable angina recurrent events; MI, myocardial infarction; NICE, National Institute for Clinical Excellence; PCI, percutaneous coronary intervention; PCI-CURE, percutaneous coronary intervention-clopidogrel in unstable angina to prevent recurrent events; PRAIS-UK, prospective registry of acute ischaemic syndromes in the UK; STEMI, ST elevation myocardial infraction; TIMI, thrombolysis in myocardial infarction
Keywords: acute coronary syndrome; clopidogrel; non-ST elevation myocardial infarction
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