HEART REVIEW

Diabetic heart disease

T H Marwick

University of Queensland, Brisbane, Australia

Correspondence to:
Professor Thomas Marwick
University of Queensland, Department of Medicine, Princess Alexandra Hospital, Ipswich Road, Brisbane, Queensland 4012, Australia; tmarwick{at}soms.uq.edu.au

Diabetes mellitus is responsible for a spectrum of cardiovascular disease. The best known complications arise from endothelial dysfunction, oxidation, inflammation, and vascular remodelling and contribute to atherogenesis. However, the effects on the heart also relate to concurrent hypertensive heart disease, as well as direct effects of diabetes on the myocardium. Diabetic heart disease, defined as myocardial disease in patients with diabetes that cannot be ascribed to hypertension, coronary artery disease, or other known cardiac disease, is reviewed.

Keywords: diabetes mellitus; myocardium; left ventricular function; tissue characterisation

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