CORONARY ARTERY DISEASE

IgA anticardiolipin antibody is associated with the extent of daily-life ischaemia in patients with chronic coronary artery disease

Ignatios Ikonomidis¹, John Lekakis¹, Georgia Vamvakou¹, Sozos Loizou², Ioanna Revela¹, Felicita Andreotti², Dimitrios T Kremastinos¹, Petros Nihoyannopoulos²

¹ 2nd Cardiology Department, Attikon Hospital, University of Athens, Greece
² Imperial College School of Medicine, National Heart & Lung Institute, Cardiology Department, Hammersmith Hospital, London, UK

Correspondence to:
Ignatios Ikonomidis, 2nd Cardiology Department, Attikon Hospital, University of Athens, Perikleous 19, N. Chalkidona, Athens, 14343, Greece; ignoik{at}otenet.gr

Background: Circulating anticardiolipin antibodies (aCL) may cause endothelial dysfunction. We investigated whether aCL are related to platelet activation, thrombin generation and daily-life ischaemia in patients with chronic coronary artery disease (CAD).

Methods: We measured (medians 25th–75th percentile) IgG, IgM, IgA aCL serum levels (Arbitrary Elisa Units, AEU), prothrombin fragments (F1+2, nmol/l), 24 h urine excretion of 11-dehydrothromboxane B2 (11-DHTXB2, ng/mg creatinine) creatine kinase (CK) and its cardiac isoenzyme CK-MB (IU/l) in 60 patients with angiographically documented CAD and in 40 age and sex matched controls. Patients underwent a 48 h Holter monitoring for assessment of the number and duration of ischaemic episodes.

Results: Patients had higher IgA-aCL levels than controls (3.2 vs 2.4 AEU, p = 0.002). Increased IgA-ACA levels were related to increased number and duration of ischaemic episodes (p<0.01). By ANOVA, patients with 10 ischaemic episodes (3rd tertile) or duration of ischaemia 32min (3rd tertile) had higher IgA-aCL than those with lower ischaemic burden (4.95 vs 3 vs 2.5 AEU, p = 0.002 and 4.9 vs 3 vs 2.5 AEU, p = 0.001 respectively). Patients with 2 ischaemic episodes (2nd and 3rd tertile) had higher 11-DHTXB2, than those with minimal ischaemia (2< episodes, 1st tertile) (p = 0.001). CK and CK-MB were within normal range after Holter monitoring. Receiver operating curve analysis showed a greater area under the curve for IgA-aCL than for 11-DHTXB2 in predicting severe ischaemia (10 ischemic episodes or 32 min duration of ischaemia).

Conclusion: Increasing IgA-aCL levels are associated with increasing ischemic burden in patients with CAD.

Abbreviations: aCL, anticardiolipin antibodies; AUC, areas under the curves; CK, creatine kinase; HM, Holter monitoring; ROC, receiver operating characteristic curve

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?