Heart 2007;93:659-664
HEART REVIEW
Cell death in the cardiovascular system
Division of Cardiovascular Medicine, Addenbrooke’s Centre for Clinical Investigation, University of Cambridge, Cambridge, UK
Correspondence to:
Dr T Littlewood
University of Cambridge, ACCI, Level 6 Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK; tdl2{at}mole.bio.cam.ac.uk
Cell death is important for both development and tissue homeostasis in the adult. As such, it is tightly controlled and deregulation is associated with diverse pathologies; for example, regulated cell death is involved in vessel remodelling during development or following injury, but deregulated death is implicated in pathologies such as atherosclerosis, aneurysm formation, ischaemic and dilated cardiomyopathies and infarction. We describe the mechanisms of cell death and its role in the normal physiology and various pathologies of the cardiovascular system.
Abbreviations: EC, endothelial cell; ECM, extracellular matrix; MI, myocardial infarction; NO, nitric oxide; oxLDL, oxidised low-density lipoprotein; TNF, tumour necrosis factor; VEGF, vascular endothelial growth factor; VSMC, vascular smooth muscle cell
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Clarke, M. C.H., Bennett, M. R.
(2009). Cause or Consequence: What Does Macrophage Apoptosis Do in Atherosclerosis?. Arterioscler. Thromb. Vasc. Bio.
29: 153-155
[Full Text] -
Duan, S. Z., Usher, M. G., Mortensen, R. M.
(2008). Peroxisome Proliferator-Activated Receptor-{gamma}-Mediated Effects in the Vasculature. Circ. Res.
102: 283-294
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
hrt.2006.088203v1
93/6/659 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
