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Instantaneous effects of resynchronisation therapy on exercise performance in heart failure patients: the mechanistic role and predictive power of total isovolumic time

¹ National Heart and Lung Institute, Imperial College, London, UK
² Royal Brompton Hospital, London, UK
³ International Centre for Circulatory Health, St. Mary’s Hospital, London, UK

Correspondence to:
Dr T V Salukhe, National Heart Lung Institute, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK; t.salukhe{at}imperial.ac.uk

ABSTRACT
Background: Cardiac resynchronisation therapy improves peak oxygen uptake (peak VO₂) 3–9 months after device implantation. In chronic heart failure, total isovolumic time (t-IVT) is a major determinant of peak VO₂ and of cardiac output at peak dobutamine stress. In selected patients, resynchronisation can instantaneously shorten t-IVT. We sought to determine the acute effect of resynchronisation on exercise performance and determine, with pharmacological stress echocardiography, the mechanism underlying this effect.

Methods and results: Twenty-two patients with resynchronisation were studied within 3 months after device implantation. On a single study day, sequential cardiopulmonary exercise tests were performed during native activation (left bundle branch block) and resynchronisation (atrio-biventricular pacing) in random order. Total-IVT and cardiac output (at rest and peak dobutamine stress) were then measured in each activation mode.

Resynchronisation acutely increased peak VO₂ by 1.6 (SD 1.5) ml/kg/min (p<0.001) and shortened peak stress t-IVT by 10 (SD 7) s/min (p<0.001), with the effects in individual patients showing a correlation (r = –0.46, p<0.05). Amongst all measurements during native activation, the best predictor of gain in peak VO₂ from resynchronisation was peak stress t-IVT (r = 0.71, p<0.001) with every increment of 5 s/min of peak stress t-IVT during native activation predicting an 8% gain in peak VO₂. No conventional measures during native activation at rest or on stress (including QRS duration, Tei index, tissue Doppler intraventricular delay, and resting t-IVT) added significant additional information.

Conclusions: In eligible patients, resynchronisation can acutely augment peak VO₂, possibly through a mechanism of t-IVT shortening. Under native activation, long t-IVT during peak stress is the single best predictor of acute resynchronisation-mediated increment in peak VO₂.

Keywords: resynchronisation; exercise performance; stress echocardiography; total isovolumic time

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Resynchronisation therapy in heart failure: searching for predictors

Min Pu and William T Abraham
Heart 2008 94: 4-5. [Extract] [Full Text] [PDF]

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				R Chung, R Sutton, and M Y Henein Beyond dyssynchrony in cardiac resynchronisation therapy Heart, August 1, 2008; 94(8): 991 - 994. [Abstract] [Full Text] [PDF]

				G. Bajraktari, A. Duncan, J. Pepper, and M. Henein Prolonged total isovolumic time predicts cardiac events following coronary artery bypass surgery Eur J Echocardiogr, May 1, 2008; (2008) jen146v1. [Abstract] [Full Text] [PDF]

				M. Pu and W. T Abraham Resynchronisation therapy in heart failure: searching for predictors Heart, January 1, 2008; 94(1): 4 - 5. [Full Text] [PDF]