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Published Online First: 24 July 2008. doi:10.1136/hrt.2008.154385
Heart 2008;94:1269-1275
Copyright © 2008 BMJ Publishing Group Ltd & British Cardiovascular Society

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Prevention of hypertrophic cardiomyopathy-related deaths: theory and practice

P Elliott1, P Spirito2

1 The Heart Hospital, University College London, UK
2 Division of Cardiology, Ospedali Galliera, Genoa, Italy

Dr Perry Elliott, The Heart Hospital, 16-18 Westmoreland Street, London W1G 8PH, UK; pelliott{at}doctors.org.uk

In 1958, the British forensic pathologist, Donald Teare, reported a family in which eight young people had died suddenly from asymmetrical hypertrophy of the left ventricle. Five decades on, the prevention of premature death from ventricular tachyarrhythmia, heart failure and stroke remains a major aim of clinical management in what is now called hypertrophic cardiomyopathy. In this paper, we review the underlying mechanisms of death and discuss the strengths and weaknesses of current international guidelines for the identification and treatment of high-risk patients.


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This article has been cited by other articles:

  • Ommen, S. R., Gersh, B. J. (2009). Sudden cardiac death risk in hypertrophic cardiomyopathy. Eur Heart J 30: 2558-2559 [Full Text]  
  • O'Mahony, C., Elliott, P. (2009). The quest for perfection: the contribution of the electrocardiogram to the prevention of sudden death in hypertrophic cardiomyopathy. Europace 11: 548-549 [Full Text]  
  • Ward, D (2009). Risk assessment in hypertrophic cardiomyopathy. Heart 95: 421-421 [Full Text]  
  • Saumarez, R C (2009). Risk assessment in hypertrophic cardiomyopathy. Heart 95: 421-421 [Full Text]  
  • Elliott, P, Spirito, P (2009). The authors' reply. Heart 95: 421-421 [Full Text]  
  • Kaludercic, N., Reggiani, C., Paolocci, N. (2009). Genes, Geography and Geometry: The "Critical Mass" in Hypertrophic Cardiomyopathy. J. Mol. Diagn. 11: 12-16 [Abstract] [Full Text]  

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Risk assessment in HCM
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