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Heart. Published Online First: 26 October 2009. doi:10.1136/hrt.2009.178624
Copyright © 2009 BMJ Publishing Group Ltd & British Cardiovascular Society
Heart 2009;0:hrt.2009.178624
© 2009 by BMJ Publishing Group & British Cardiac Society

Editorial

Clopidogrel and Calcium Channel Blockers - a Clinically Important Interaction?

Neil Chapman1,*, Michael Schachter2

1 St Mary's Hospital, Imperial College Healthcare NHS Trust, United Kingdom;
2 Imperial College, United Kingdom

Correspondence to: Neil Chapman, Clinical Pharmacology, St Mary's Hospital, St Mary's Hospital, London, W2 1NY, United Kingdom; neil.chapman{at}imperial.nhs.uk

Accepted 13 October 2009

ABSTRACT

Antiplatelet therapy plays a pivotal role in modern management of coronary artery disease and use of clopidogrel has facilitated the emergence of intravascular stenting as common cardiological practice. However, clopidogrel responsiveness is heterogeneous within the population, with a sizable proportion seemingly non-responsive to its antiplatelet effects and at higher risk of cardiovascular events as a result [1, 2].


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