Heart 1998;79:5-6 ( January )
Editorial
Blocking platelets more: are we skating on thin ice?
| The first 150 words of the full text of this article appear below. |
Over the past century, the enormous success of aspirin was mainly
due to its analgesic and anti-inflammatory properties. However, aspirin
has triumphed during the past decade in the prevention and treatment of
platelet mediated arterial events. The modern history of aspirin may
have started with the ISIS-2 trial and antiplatelet treatment in
vascular diseases has rapidly become a monopoly for aspirin as no other
drug compares favourably in terms of both risk:benefit and
cost-effectiveness analyses.1 Indeed, only one study
compared ticlopidine and aspirin head to head showing a borderline
superiority for ticlopidine in a high risk population with
cerebrovascular disease.2 The other studies conducted with
either drug were placebo controlled and demonstrated relative risk
reductions for the composite outcome of stroke, myocardial infarction
or vascular death of 33% with ticlopidine and 25% with aspirin. This
difference of efficacy was used to calculate the
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