Heart 1998;79:538-540 ( June )
Editorial
Sudden death in hypertrophic cardiomyopathy: potential importance of altered autonomic control of vasculature
| The first 150 words of the full text of this article appear below. |
Donald Teare's original pathological description of
hypertrophic cardiomyopathy (HCM) was based on eight young adults,
seven of whom died suddenly.1 Almost 40 years later, the
identification of individuals at risk for sudden death and its
effective prevention remains the major therapeutic challenge in this
disorder. While HCM is, in most series, the most common cause of sudden
death in asymptomatic young adults, adolescents and
athletes,2 the annual risk of sudden death for patients
with HCM is not certain. Annual incidences of 1-2% in adults and
4-6% in children and adolescents have been reported from tertiary
centres.2 Recent natural history studies from non-referral
centres however indicate a better prognosis.3 This in part
reflects referral bias as well as increased recognition of the disease.
HCM has been considered a rare disease with adverse prognosis; however,
emerging data from a number of studies suggest that it is a common
disease (~ 1 in 500; estimated
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