Heart 1998;80:110-111 ( August )
Editorial
Olovnikov's clock: telomeres and vascular biology
| The first 150 words of the full text of this article appear below. |
The
proliferation, migration, and death of vascular endothelial and smooth
muscle cells are crucial to the development of atherosclerosis and its
related processes such as postangioplasty restenosis. While a great
deal of attention has been paid to many of the factors that influence
these events, relatively little attention has been given to one
potentially important factor, the age of the cells concerned. Cell age
is more appropriately measured in terms of the number of divisions
since the cell differentiated from the germ line than in terms of
chronological age. Following the work of Hayflick in the 1960s it has
been known that virtually all somatic cells in culture go through a
finite number of cell divisions and then enter a phase of senescence in
which they are no longer susceptible to ordinary mitotic stimuli, and
indeed where such stimuli can provoke cell death.1,2 This
M1 phase is now thought to
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