Heart 1999;81:10-11 ( January )
Editorial
Lipid modification and coronary heart disease in type 2 diabetes: different from the general population?
| The first 150 words of the full text of this article appear below. |
Patients with non-insulin dependent (type 2) diabetes have a 2-5-fold increase in age adjusted mortality from coronary heart disease (CHD).1,2 CHD accounts for up to 70% of the observed mortality in these patients.1,2 The distinct metabolic background of type 2 diabetes appears to be of pathophysiological importance in producing this excess of CHD, and therefore should provide the key to therapeutic intervention for reducing its incidence.
Type 2 diabetes is characterised by, in addition to hyperglycaemia,
raised serum triglycerides and reduced high density lipoprotein (HDL)
cholesterol compared to people without diabetes.3-5 In contrast, total and low density lipoprotein (LDL) cholesterol concentrations are usually similar to those found in non-diabetic subjects.3-5 The importance of this increase in
triglycerides is the metabolic link with the production of remnant
particles that are highly atherogenic, a reduced HDL cholesterol, and
the production of small dense LDL.5 It is the small dense
LDL species (or LDL-III) of
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Elkeles, R. S, Flather, M., Feher, M. D, Godsland, I., Richmond, W., Humphries, S. E, Rubens, M. B, Underwood, S R.
(2002). Prospective evaluation of diabetic ischaemic heart disease by computed tomography: the PREDICT study. British Journal of Diabetes & Vascular Disease
2: 69-72a
[Abstract] -
Timmis, A. D
(2001). Diabetes: Relationship to ischaemic heart disease. Br Med Bull
59: 159-172
[Abstract] [Full Text] -
Kirby, M.
(2001). Commentary: Audit of mortality in type 2 diabetes. British Journal of Diabetes & Vascular Disease
1: 55-56
-
Zambanini, A., Smith, M. R, Feher, M. D, Gueyffier, F., Boissel, J.-P., Hingorani, A. D, Vallance, P.
(1999). Prediction of cardiovascular risk. BMJ
318: 1418-1418
[Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Diabetes
-
Drugs: cardiovascular system
-
Epidemiology
-
Metabolic disorders
- Stable coronary heart disease
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
