Heart 1999;81:6-7 ( January )
Editorial
Radionuclide techniques for myocardial viability and hibernation
| The first 150 words of the full text of this article appear below. |
In hibernation there is a persistent, reversible abnormality of contraction of viable myocardium that normalises upon revascularisation. It may be short term, in which case no ultrastructural changes occur, or long term when myofibrils are disorganised and reduced in number, and myocardial glucose content and extracellular collagen are increased. There is usually some preservation of flow reserve, and hibernating myocardium generally responds to inotropic stimulation with an increase in contraction.
In myocardial stunning there is transient depression of ventricular contraction which is induced by ischaemia and which persists after the ischaemic insult, despite the absence of irreversible damage and the restoration of normal or near normal perfusion.
Although the concepts of hibernation and stunning are superficially
distinct, in reality there is considerable overlap. In contrast to
earlier expectations which imagined that hibernation was an adaptive
response to a chronic reduction of blood flow, recent work has
demonstrated that akinetic or
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