Review
Potential interests of heart rate lowering drugs
Cardiology
Department, Hôpital Beaujon, 100 bd du Général Leclerc, Clichy,
France
Correspondence to: Dr T Laperche, Centre Cardiologique du Nord, 32-36 rue des Moulins Gémeaux, 93200 Saint Denis, France.
Accepted for publication 8 October 1998
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Epidemiological studies have shown that a high heart rate at rest is a risk factor for global and cardiovascular mortality.1-3 A rapid heart rate is associated with a variety of prognostic factors indicative of worse heart conditions (for example, hypoxaemia, anaemia, alcohol consumption, low physical training status). The link between a high resting heart rate and an increase in overall and cardiovascular mortality has, however, been shown to be independent of cardiac conditions that can contribute to an increase in the resting heart rate, and persists after adjustment for other classic variables (sex, arterial pressure, and alcohol consumption).2 3
Recently, an elegant study showed that, among mammals, the relation
between the number of beats per lifetime and life expectancy was
remarkably constant, and the provocative question was raised as whether
human life could be extended by slowing the heart rate.4 Of course, such a study using bradycardiac drugs has not yet
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