Editorial
Dynamic cardiomyoplasty: time to wrap it up?
| The first 150 words of the full text of this article appear below. |
Fifteen
years ago Larry Stevenson, in his memorable lectures, pointed to the
great sheet of muscle that is the latissimus dorsi, and proposed that
this potential power source should be harnessed for the purpose of
circulatory assistance, and put to much better use as a cardiac muscle
in patients handicapped and dying of heart failure.1
Salmons and others2 3 had demonstrated that this fast
twitch fatiguable muscle retained within its genome the potential to be
transformed into a slow contracting, fatigue resistant phenotype,
similar to cardiac muscle. The logic seemed inescapable. It seemed
inevitable that this resource would be used routinely to rescue the
many with shortened miserable lives because of end stage heart
failure.4 The combination of advances in muscle
physiology, electronic engineering, and experimental surgery,5-7 culminated in 1985 in the first successful
use of stimulated skeletal muscle to aid the circulation8
in a patient with a left ventricular defect following
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[Abstract] [Full Text]
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