Review
Postinfarction left ventricular remodelling: where are the theories and trials leading us?
Z R Yousef, S R Redwood, M S Marber
Department of
Cardiology, The Rayne Institute, St Thomas' Hospital, King's College
London, London SE1 7EH, UK
Correspondence to: Professor Marber email: mike.marber@kcl.ac.uk
Accepted 21 July 1999
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
While mortality from overt ischaemic heart disease is falling, that from heart failure is increasing and reaching epidemic proportions.1 Although an aging population is partly responsible for this trend, recent observations showing persistently high mortality and morbidity rates following myocardial infarction further compounds the issue.2 An understanding of the pathophysiological processes leading to heart failure, and in particular the mechanisms underlying postinfarction heart failure (postinfarction ventricular remodelling) is therefore fundamental and forms the basis of this review.
| |
Acute myocardial infarction |
|---|
Immediately after coronary artery occlusion, irreversible cell necrosis can occur within minutes. Factors affecting the amount of necrosis include the presence or absence of a preconditioning stimulus,3 the volume of ischaemic myocardium, and the amount of collateral blood flow.4 In addition, prompt reperfusion within a narrow time window, when myocytes are in a state of critical ischaemia and are prenecrotic/viable, has been shown to reduce cell death, limit infarct size, and increase survival.5
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Bujak, M., Ren, G., Kweon, H. J., Dobaczewski, M., Reddy, A., Taffet, G., Wang, X.-F., Frangogiannis, N. G.
(2007). Essential Role of Smad3 in Infarct Healing and in the Pathogenesis of Cardiac Remodeling. Circulation
116: 2127-2138
[Abstract] [Full Text] -
Yamaguchi, A., Adachi, H., Kawahito, K., Murata, S., Ino, T.
(2005). Left Ventricular Reconstruction Benefits Patients With Dilated Ischemic Cardiomyopathy. Ann. Thorac. Surg.
79: 456-461
[Abstract] [Full Text] -
Tsuda, T., Gao, E., Evangelisti, L., Markova, D., Ma, X., Chu, M.-L.
(2003). Post-ischemic myocardial fibrosis occurs independent of hemodynamic changes. Cardiovasc Res
59: 926-933
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
