Editorial
Homocysteine, B vitamins, and risk of cardiovascular disease
| The first 150 words of the full text of this article appear below. |
Homocysteine is a sulphur containing amino acid that plays an important role in methionine and folate metabolism.1 By receiving a methyl group from 5'-methyltetrahydrofolate, it is reconverted to methionine (fig 1), which is essential for many biochemical reactions critical to the formation of protein, nucleic acids, and creatinine. Reconversion of homocysteine to methionine also contributes to the maintenance of intracellular stores of tetrahydrofolate.
| Figure Removed (Available Only in the Full Text) |
Homocysteine has become a target for many basic and clinical
investigators because of a clinical syndrome described almost 40 years
ago.2 3 The syndrome, homocystinuria, is an autosomal recessive disorder characterised by abnormalities of the long bones,
ocular lens dislocation, mental retardation, and aggressive vascular disease, in particular venous thromboembolism. The underlying enzymological abnormality, a deficit of cystathionine 
synthase, results in impairment of homocysteine transsulfuration. As a
consequence, the concentrations of the amino acid in plasma may rise
20-fold from the normative range of 5-15 µmol/l. About 10 years
after
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