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Heart 2000;83:371-373 ( April )

Editorial

Troponin T or troponin I as cardiac markers in ischaemic heart disease

The first 150 words of the full text of this article appear below.

There is increasing awareness of the limitations of standard biochemical markers of cardiac damage in patients with acute coronary syndromes. A desire to improve sensitivity and specificity has led to the search for markers uniquely expressed by the myocardium. The cardiac troponins T and I (cTnT and cTnI) have been found to have excellent sensitivity and specificity and are superior to creatine kinase-MB (CK-MB) as indicators of myocardial necrosis.1 Using cTnT or cTnI as a diagnostic marker, the positivity rate in studies has varied from 20-48%, with death and acute myocardial infarction (MI) varying from 11-30% in 28 months follow up.2-4 These variations are largely caused by differences in risk among the populations studied and differing lengths of follow up.

Troponins have proven useful for the diagnosis and subsequent risk stratification of patients presenting with acute chest pain.5 6 A raised troponin concentration may also identify those who are most likely to . . . [Full text of this article]


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