Heart 2000;83:381-387 ( April )

Review

Protecting the ischaemic and reperfused myocardium in acute myocardial infarction: distant dream or near reality?

D M Yellon, G F Baxter

The Hatter Institute, Department of Academic & Clinical Cardiology, University College London Hospitals & Medical School, Grafton Way, London WC1E 6DB, UK

Correspondence to: Professor Yellon email: hatter-institute@ucl.ac.uk

Accepted 6 January 2000

The first 150 words of the full text of this article appear below.

	Introduction

Acute coronary occlusion is the leading cause of morbidity and mortality in the Western world, and according to the World Health Organisation will be the major cause of death in the world as a whole by the year 2020.¹ Although the management of this epidemic will centre on the development of effective primary prevention programmes, the impact of these strategies may be limited, particularly in the developing countries. There is an urgent need for effective forms of secondary prevention and, in particular, treatments which will limit the extent of an evolving myocardial infarction during the acute phase of coronary occlusionthe death of myocardium represents a catastrophic event since dead myocytes are not replaced by division of surviving myocytes. Preserving the viability of ischaemic myocardium therefore presents a therapeutic target. Although appreciated for many years, this concept has so far failed to produce a clinically useful agent capable of protecting . . . [Full text of this article]

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