Education in Heart
HEART FAILUREEpidemiology, aetiology, and prognosis of heart failure
John J McMurray, Simon Stewart
Clinical Research Initiative in Heart Failure, Wolfson
Building, University of Glasgow, Glasgow,
UK
Correspondence to: Professor John J McMurray, The Clinical Research Initiative in Heart Failure, Wolfson Building, University of Glasgow, Glasgow, United Kingdom, G12 8QQ, UK email: J.McMurray@bio.gla.ac.uk
| The first 150 words of the full text of this article appear below. |
| |
Introduction |
|---|
Heart
failure is now recognised as a major and escalating public health
problem in industrialised countries with ageing populations. Any
attempt to describe the epidemiology, aetiology, and prognosis of heart
failure, however, must take account of the difficulty in defining
exactly what heart failure is. Though the focus of this article is the
symptomatic syndrome it must be remembered that as many patients again
may have asymptomatic disease that might be legitimately labelled
"heart failure"
for example, asymptomatic left ventricular
systolic dysfunction. More comprehensive reviews of the epidemiology
and associated burden of heart failure have been published by McMurray
and colleagues1 and more recently by Cowie and
colleagues.2
Data relating to the aetiology, epidemiology and prognostic implications of heart failure are principally available from five types of studies:
- Cross sectional and longitudinal follow up surveys of
well defined populations. These have almost exclusively focused on
those individuals with clinical signs
. . . [Full text of this article]
This article has been cited by other articles:
-
Chaggar, P. S., Shaw, S. M., Williams, S. G.
(2009). Review article: Thiazolidinediones and heart failure. Diabetes and Vascular Disease Research
6: 146-152
[Abstract] -
Clark, A. M., Freydberg, C. N., McAlister, F. A., Tsuyuki, R. T., Armstrong, P. W., Strain, L. A.
(2009). Patient and informal caregivers' knowledge of heart failure: necessary but insufficient for effective self-care. Eur J Heart Fail
11: 617-621
[Abstract] [Full Text] -
Adlbrecht, C., Hulsmann, M., Strunk, G., Berger, R., Mortl, D., Struck, J., Morgenthaler, N. G., Bergmann, A., Jakowitsch, J., Maurer, G., Lang, I. M., Pacher, R.
(2009). Prognostic value of plasma midregional pro-adrenomedullin and C-terminal-pro-endothelin-1 in chronic heart failure outpatients. Eur J Heart Fail
11: 361-366
[Abstract] [Full Text] -
Basile, C., Chimienti, D., Bruno, A., Cocola, S., Libutti, P., Teutonico, A., Cazzato, F.
(2009). Efficacy of Peritoneal Dialysis with Icodextrin in the Long-Term Treatment of Refractory Congestive Heart Failure. pdi
29: 116-118
[Full Text] -
Stewart, S., Wilkinson, D., Hansen, C., Vaghela, V., Mvungi, R., McMurray, J., Sliwa, K.
(2008). Predominance of Heart Failure in the Heart of Soweto Study Cohort: Emerging Challenges for Urban African Communities. Circulation
118: 2360-2367
[Abstract] [Full Text] -
Pegg, T. J., Selvanayagam, J. B., Francis, J. M., Karamitsos, T. D., Maunsell, Z., Yu, L.-M., Neubauer, S., Taggart, D. P.
(2008). A Randomized Trial of On-Pump Beating Heart and Conventional Cardioplegic Arrest in Coronary Artery Bypass Surgery Patients With Impaired Left Ventricular Function Using Cardiac Magnetic Resonance Imaging and Biochemical Markers. Circulation
118: 2130-2138
[Abstract] [Full Text] -
Simantirakis, E. N., Schiza, S. E., Siafakas, N. S., Vardas, P. E.
(2008). Sleep-disordered breathing in heart failure and the effect of cardiac resynchronization therapy. Europace
10: 1029-1033
[Abstract] [Full Text] -
De Mello, W. C.
(2008). Metallothionein Reverses the Harmful Effects of Angiotensin II on the Diabetic Heart. J Am Coll Cardiol
52: 667-669
[Full Text] -
Thomas, S. A., Chapa, D. W., Friedmann, E., Durden, C., Ross, A., Lee, M. C. Y., Lee, H.-J.
(2008). Depression in Patients With Heart Failure: Prevalence, Pathophysiological Mechanisms, and Treatment. Crit Care Nurse
28: 40-55
[Full Text] -
Ryder, M., Murphy, N. F., McCaffrey, D., O'Loughlin, C., Ledwidge, M., McDonald, K.
(2008). Outpatient intravenous diuretic therapy; potential for marked reduction in hospitalisations for acute decompensated heart failure. Eur J Heart Fail
10: 267-272
[Abstract] [Full Text] -
Clark, R. A., Yallop, J. J., Piterman, L., Croucher, J., Tonkin, A., Stewart, S., Krum, H., CHAT Study Team,
(2007). Adherence, adaptation and acceptance of elderly chronic heart failure patients to receiving healthcare via telephone-monitoring. Eur J Heart Fail
9: 1104-1111
[Abstract] [Full Text] -
Lee, D. S., Massaro, J. M., Wang, T. J., Kannel, W. B., Benjamin, E. J., Kenchaiah, S., Levy, D., D'Agostino, R. B. Sr, Vasan, R. S.
(2007). Antecedent Blood Pressure, Body Mass Index, and the Risk of Incident Heart Failure in Later Life. Hypertension
50: 869-876
[Abstract] [Full Text] -
Selman, L., Harding, R., Beynon, T., Hodson, F., Coady, E., Hazeldine, C., Walton, M., Gibbs, L., Higginson, I. J
(2007). Improving end-of-life care for patients with chronic heart failure: "Let's hope it'll get better, when I know in my heart of hearts it won't". Heart
93: 963-967
[Abstract] [Full Text] -
Selman, L., Harding, R., Beynon, T., Hodson, F., Hazeldine, C., Coady, E., Gibbs, L., Higginson, I. J.
(2007). Modelling services to meet the palliative care needs of chronic heart failure patients and their families: current practice in the UK. Palliat Med
21: 385-390
[Abstract] -
Patel, H., Shafazand, M., Schaufelberger, M., Ekman, I.
(2007). Reasons for seeking acute care in chronic heart failure. Eur J Heart Fail
9: 702-708
[Abstract] [Full Text] -
Murphy, A., McMurray, J. J.V.
(2007). Heart failure: are we neglecting the silent majority?. Eur Heart J
28: 1047-1048
[Full Text] -
Holzapfel, N., Zugck, C., Muller-Tasch, T., Lowe, B., Wild, B., Schellberg, D., Nelles, M., Remppis, A., Katus, H., Herzog, W., Junger, J., The German Heart Failure Network*,
(2007). Routine Screening for Depression and Quality of Life in Outpatients With Congestive Heart Failure. Psychosomatics
48: 112-116
[Abstract] [Full Text] -
Gaziano, T. A.
(2007). Reducing The Growing Burden Of Cardiovascular Disease In The Developing World. Health Aff (Millwood)
26: 13-24
[Abstract] [Full Text] -
Field, K., Ziebland, S., McPherson, A., Lehman, R.
(2006). 'Can I come off the tablets now?' A qualitative analysis of heart failure patients' understanding of their medication. Fam Pract
23: 624-630
[Abstract] [Full Text] -
Falk, K., Swedberg, K., Gaston-Johansson, F., Ekman, I.
(2006). Fatigue and anaemia in patients with chronic heart failure. Eur J Heart Fail
8: 744-749
[Abstract] [Full Text] -
Aspromonte, N., Ceci, V., Chiera, A., Coletta, C., D'Eri, A., Feola, M., Giovinazzo, P., Milani, L., Noventa, F., Scardovi, A. B., Sestili, A., Valle, R.
(2006). Rapid Brain Natriuretic Peptide Test and Doppler Echocardiography for Early Diagnosis of Mild Heart Failure. Clin. Chem.
52: 1802-1808
[Abstract] [Full Text] -
Silke, B.
(2006). Beta-blockade in CHF: pathophysiological considerations. Eur Heart J Suppl
8: C13-C18
[Abstract] [Full Text] -
Poornima, I. G., Parikh, P., Shannon, R. P.
(2006). Diabetic Cardiomyopathy: The Search for a Unifying Hypothesis. Circ. Res.
98: 596-605
[Abstract] [Full Text] -
Malkin, C. J., Pugh, P. J., West, J. N., van Beek, E. J.R., Jones, T. H., Channer, K. S.
(2006). Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial. Eur Heart J
27: 57-64
[Abstract] [Full Text] -
Sturm, H. B., Haaijer-Ruskamp, F. M., Veeger, N. J., Balje-Volkers, C. P., Swedberg, K., van Gilst, W. H.
(2006). The relevance of comorbidities for heart failure treatment in primary care: A European survey. Eur J Heart Fail
8: 31-37
[Abstract] [Full Text] -
Ingelsson, E., Arnlov, J., Sundstrom, J., Zethelius, B., Vessby, B., Lind, L.
(2005). Novel Metabolic Risk Factors for Heart Failure. J Am Coll Cardiol
46: 2054-2060
[Abstract] [Full Text] -
Stromberg, A.
(2005). Heart failure management programmes: The time for action has arrived. Eur J Heart Fail
7: 1077-1078
[Full Text] -
Remme, W. J., McMurray, J. J.V., Rauch, B., Zannad, F., Keukelaar, K., Cohen-Solal, A., Lopez-Sendon, J., Hobbs, F.D. R., Grobbee, D. E., Boccanelli, A., Cline, C., Macarie, C., Dietz, R., Ruzyllo, W.
(2005). Public awareness of heart failure in Europe: first results from SHAPE. Eur Heart J
26: 2413-2421
[Abstract] [Full Text] -
Dimarakis, I., Habib, N. A., Gordon, M. Y.A.
(2005). Adult bone marrow-derived stem cells and the injured heart: just the beginning?. Eur. J. Cardiothorac. Surg.
28: 665-676
[Abstract] [Full Text] -
Ferrier, K., Campbell, A., Yee, B., Richards, M., O'Meeghan, T., Weatherall, M., Neill, A.
(2005). Sleep-Disordered Breathing Occurs Frequently in Stable Outpatients With Congestive Heart Failure. Chest
128: 2116-2122
[Abstract] [Full Text] -
Davidson, P., Paull, G., Rees, D., Daly, J., Cockburn, J.
(2005). Activities of Home-Based Heart Failure Nurse Specialists: A Modified Narrative Analysis. Am J Crit Care
14: 426-433
[Abstract] [Full Text] -
Altimir, S., Lupon, J., Gonzalez, B., Prats, M., Parajin, T., Urrutia, A., Coll, R., Valle, V.
(2005). Sex and age differences in fragility in a heart failure population. Eur J Heart Fail
7: 798-802
[Abstract] [Full Text] -
Kintsurashvili, E., Duka, A., Ignjacev, I., Pattakos, G., Gavras, I., Gavras, H.
(2005). Age-related changes of bradykinin B1 and B2 receptors in rat heart. Am. J. Physiol. Heart Circ. Physiol.
289: H202-H205
[Abstract] [Full Text] -
Valle, R., Aspromonte, N., Barro, S., Canali, C., Carbonieri, E., Ceci, V., Chinellato, M., Gallo, G., Giovinazzo, P., Ricci, R., Milani, L.
(2005). The NT-proBNP assay identifies very elderly nursing home residents suffering from pre-clinical heart failure. Eur J Heart Fail
7: 542-551
[Abstract] [Full Text] -
Verdiani, V., Nozzoli, C., Bacci, F., Cecchin, A., Rutili, M. S., Paladini, S., Olivotto, I.
(2005). Pre-discharge B-type natriuretic peptide predicts early recurrence of decompensated heart failure in patients admitted to a general medical unit. Eur J Heart Fail
7: 566-571
[Abstract] [Full Text] -
Dunderdale, K., Thompson, D. R., Miles, J. N.V., Beer, S. F., Furze, G.
(2005). Quality-of-life measurement in chronic heart failure: do we take account of the patient perspective?. Eur J Heart Fail
7: 572-582
[Abstract] [Full Text] -
Molloy, G. J., Johnston, D. W., Witham, M. D.
(2005). Family caregiving and congestive heart failure. Review and analysis. Eur J Heart Fail
7: 592-603
[Abstract] [Full Text] -
Leslie, S J, McKee, S P, Imray, E A, Denvir, M A
(2005). Management of chronic heart failure: perceived needs of general practitioners in light of the new general medical services contract. Postgrad. Med. J.
81: 321-326
[Abstract] [Full Text] -
Zannad, F.
(2005). Acute heart failure syndromes: the 'Cinderella' of heart failure research. Eur Heart J Suppl
7: B8-B12
[Abstract] [Full Text] -
Ledwidge, M., Ryan, E., O'Loughlin, C., Ryder, M., Travers, B., Kieran, E., Walsh, A., McDonald, K.
(2005). Heart failure care in a hospital unit: a comparison of standard 3-month and extended 6-month programs. Eur J Heart Fail
7: 385-391
[Abstract] [Full Text] -
Roman-Sanchez, P., Conthe, P., Garcia-Alegria, J., Forteza-Rey, J., Montero, M., Montoto, C., for the Heart Failure Working Group of the Spanish,
(2005). Factors influencing medical treatment of heart failure patients in Spanish internal medicine departments: a national survey. QJM
98: 127-138
[Abstract] [Full Text] -
Poelzl, G., Frick, M., Huegel, H., Lackner, B., Alber, H. F., Mair, J., Herold, M., Schwarzacher, S., Pachinger, O., Weidinger, F.
(2005). Chronic heart failure is associated with vascular remodeling of the brachial artery. Eur J Heart Fail
7: 43-48
[Abstract] [Full Text] -
Bleasdale, R A, Frenneaux, M P
(2004). Cardiac resynchronisation therapy: when the drugs don't work.. Heart
90: vi2-vi4
[Full Text] -
Murphy, N F, Simpson, C R, McAlister, F A, Stewart, S, MacIntyre, K, Kirkpatrick, M, Chalmers, J, Redpath, A, Capewell, S, McMurray, J J V
(2004). National survey of the prevalence, incidence, primary care burden, and treatment of heart failure in Scotland. Heart
90: 1129-1136
[Abstract] [Full Text] -
Gonseth, J., Guallar-Castillon, P., Banegas, J. R., Rodriguez-Artalejo, F.
(2004). The effectiveness of disease management programmes in reducing hospital re-admission in older patients with heart failure: a systematic review and meta-analysis of published reports. Eur Heart J
25: 1570-1595
[Abstract] [Full Text] -
Atienza, F., Anguita, M., Martinez-Alzamora, N., Osca, J., Ojeda, S., Almenar, L., Ridocci, F., Valles, F., de Velasco, J. A.
(2004). Multicenter randomized trial of a comprehensive hospital discharge and outpatient heart failure management program. Eur J Heart Fail
6: 643-652
[Abstract] [Full Text] -
Raymond, I., Mehlsen, J., Pedersen, F., Dimsits, J., Jacobsen, J., Hildebrandt, P. R.
(2004). The prognosis of impaired left ventricular systolic function and heart failure in a middle-aged and elderly population in an urban population segment of Copenhagen. Eur J Heart Fail
6: 653-661
[Abstract] [Full Text] -
Wood, M. J, Picard, M. H
(2004). Utility of echocardiography in the evaluation of individuals with cardiomyopathy. Heart
90: 707-712
[Full Text] -
Schinkel, A F L, Vourvouri, E C, Bax, J J, Boomsma, F, Bountioukos, M, Rizzello, V, Biagini, E, Agricola, E, Elhendy, A, Roelandt, J R T C, Poldermans, D
(2004). Relation between left ventricular contractile reserve during low dose dobutamine echocardiography and plasma concentrations of natriuretic peptides. Heart
90: 293-296
[Abstract] [Full Text] -
McMurray, J. J.
(2004). Angiotensin inhibition in heart failure. Journal of Renin-Angiotensin-Aldosterone System
5: S17-S22
[Abstract] -
Raymond, I, Pedersen, F, Steensgaard-Hansen, F, Green, A, Busch-Sorensen, M, Tuxen, C, Appel, J, Jacobsen, J, Atar, D, Hildebrandt, P
(2003). Prevalence of impaired left ventricular systolic function and heart failure in a middle aged and elderly urban population segment of Copenhagen. Heart
89: 1422-1429
[Abstract] [Full Text] -
De Smet, H. R., Menadue, M. F., Oliver, J. R., Phillips, P. A.
(2003). Increased thirst and vasopressin secretion after myocardial infarction in rats. Am. J. Physiol. Regul. Integr. Comp. Physiol.
285: R1203-R1211
[Abstract] [Full Text] -
McKenzie, D B, Cowley, A J
(2003). Drug therapy in chronic heart failure. Postgrad. Med. J.
79: 634-642
[Abstract] [Full Text] -
Senior, R, Galasko, G, McMurray, J V, Mayet, J
(2003). Screening for left ventricular dysfunction in the community: role of hand held echocardiography and brain natriuretic peptides. Heart
89: iii24-28
[Full Text] -
Vasan, R. S., Sullivan, L. M., D'Agostino, R. B., Roubenoff, R., Harris, T., Sawyer, D. B., Levy, D., Wilson, P. W.F.
(2003). Serum Insulin-like Growth Factor I and Risk for Heart Failure in Elderly Individuals without a Previous Myocardial Infarction: The Framingham Heart Study. ANN INTERN MED
139: 642-648
[Abstract] [Full Text] -
Ostergren, J., McMurray, J. J.
(2003). Angiotensin receptor blockers in heart failure. Journal of Renin-Angiotensin-Aldosterone System
4: 171-175
[Abstract] -
Thomas, J. A., Haudek, S. B., Koroglu, T., Tsen, M. F., Bryant, D. D., White, D. J., Kusewitt, D. F., Horton, J. W., Giroir, B. P.
(2003). IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. Am. J. Physiol. Heart Circ. Physiol.
285: H597-H606
[Abstract] [Full Text] -
Sanderson, J E, Tse, T-f
(2003). Heart failure: a global disease requiring a global response. Heart
89: 585-586
[Full Text] -
Blackledge, H M, Tomlinson, J, Squire, I B
(2003). Prognosis for patients newly admitted to hospital with heart failure: survival trends in 12 220 index admissions in Leicestershire 1993-2001. Heart
89: 615-620
[Abstract] [Full Text] -
Bolger, A. P, Coats, A. J.S, Gatzoulis, M. A
(2003). Congenital heart disease: the original heart failure syndrome. Eur Heart J
24: 970-976
[Abstract] [Full Text] -
Fuat, A., Hungin, A P. S, Murphy, J. J.
(2003). Barriers to accurate diagnosis and effective management of heart failure in primary care: qualitative study. BMJ
326: 196-196
[Abstract] [Full Text] -
Freedland, K. E., Rich, M. W., Skala, J. A., Carney, R. M., Davila-Roman, V. G., Jaffe, A. S.
(2003). Prevalence of Depression in Hospitalized Patients With Congestive Heart Failure. Psychosom. Med.
65: 119-128
[Abstract] [Full Text] -
Stewart, S., Blue, L., Walker, A., Morrison, C., Mcmurray, J.J.V.
(2002). An economic analysis of specialist heart failure nurse management in the U.K. Can we afford not to implement it?. Eur Heart J
23: 1369-1378
[Abstract] [Full Text] -
Varela-Roman, A, Gonzalez-Juanatey, J R, Basante, P, Trillo, R, Garcia-Seara, J, Martinez-Sande, J L, Gude, F
(2002). Clinical characteristics and prognosis of hospitalised inpatients with heart failure and preserved or reduced left ventricular ejection fraction. Heart
88: 249-254
[Abstract] [Full Text] -
Heiat, A., Gross, C. P., Krumholz, H. M.
(2002). Representation of the Elderly, Women, and Minorities in Heart Failure Clinical Trials. Arch Intern Med
162: 1682-1688
[Abstract] [Full Text] -
Shamim, W, Yousufuddin, M, Cicoria, M, Gibson, D G, Coats, A J S, Henein, M Y
(2002). Incremental changes in QRS duration in serial ECGs over time identify high risk elderly patients with heart failure. Heart
88: 47-51
[Abstract] [Full Text] -
Nakamura, K., Kusano, K., Nakamura, Y., Kakishita, M., Ohta, K., Nagase, S., Yamamoto, M., Miyaji, K., Saito, H., Morita, H., Emori, T., Matsubara, H., Toyokuni, S., Ohe, T.
(2002). Carvedilol Decreases Elevated Oxidative Stress in Human Failing Myocardium. Circulation
105: 2867-2871
[Abstract] [Full Text] -
Mosterd, A., Hoes, A.W.
(2002). Reducing hospitalizations for heart failure. Eur Heart J
23: 842-845
[Full Text] -
McMurray, J.J.V, Stewart, S
(2002). The burden of heart failure. Eur Heart J Suppl
4: D50-D58
[Abstract] -
Ward, C.
(2002). The need for palliative care in the management of heart failure. Heart
87: 294-298
[Full Text] -
Berkin, K E, Ball, S G
(2001). HYPERTENSION: Essential hypertension: the heart and hypertension. Heart
86: 467-475
[Full Text] -
Blue, L., Lang, E., McMurray, J. J V, Davie, A. P, McDonagh, T. A, Murdoch, D. R, Petrie, M. C, Connolly, E., Norrie, J., Round, C. E, Ford, I., Morrison, C. E
(2001). Randomised controlled trial of specialist nurse intervention in heart failure. BMJ
323: 715-718
[Abstract] [Full Text] -
GALL, N P, KEARNEY, M T, ZAMAN, A, O'NUNAIN, S, FOX, K A A, FLAPAN, A, NOLAN, J
(2001). Implementation of the NICE guidelines for the primary prevention of mortality from ventricular tachyarrhythmias: implications for UK electrophysiology centres; activity modelling from the UK-HEART study. Heart
86: 219a-220
[Full Text] -
Berry, C., Murdoch, D. R., McMurray, J. J.V.
(2001). Economics of chronic heart failure. Eur J Heart Fail
3: 283-291
[Abstract] [Full Text] -
McMurray, J.
(2000). Why we need new strategies in CHF management. Journal of Renin-Angiotensin-Aldosterone System
1: 12-16
[Abstract]
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
