Review
Management of cardiogenic shock complicating acute myocardial infarction: towards evidence based medical practice
S G Williams, D J Wright, L B Tan
Cardiology Research,
Yorkshire Heart Centre, Leeds General Infirmary, Leeds LS1 3EX, UK
Correspondence to: Dr Tan
Accepted 8
March 2000
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Introduction |
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The treatment of cardiogenic shock is the ultimate challenge of our ability to manage patients presenting with acute myocardial infarction. Despite advances in the treatment of infarcts with thrombolysis, there has been no significant decrease in the incidence of cardiogenic shock, which has remained at 7-10% during the last 20 years.1-5 Hospital mortality was over 90% in the 1970s6 and is still high, in the region of 45-80%, in the 1990s.1 7-9 Attitudes towards treatment of cardiogenic shock range from resignation, providing supportive measures only, to aggressive intervention. In the era of evidence based medical practice, are there data to support adoption of either extreme of approach?
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Registry of cardiogenic shock patients |
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The largest prospectively identified registry of patients with
cardiogenic shock so far analysed is from the GUSTO-I (global utilisation of streptokinase and tissue plasminogen activator for
occluded coronary arteries) trial.4 8 10 Of the 41 021 patients recruited into that study, 7.2% (2972) developed cardiogenic shock, with an
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