Review
Antiarrhythmics
from cell to clinic: past, present, and
future
J C Hancoxa, K C R Patela, J V Jonesb
a Department of
Physiology and Cardiovascular Research Laboratories, School of Medical
Sciences, University Walk, Bristol BS8 1TD, UK, b Department of Cardiology,
Bristol Royal Infirmary, United Bristol Healthcare Trust, Bristol, UK
Correspondence to: Dr Hancox email: jules.hancox@bristol.ac.uk
Accepted 29 February 2000
| The first 150 words of the full text of this article appear below. |
 |
Introduction |
|---|
The
past two decades have witnessed a rapid growth in understanding of the
cellular and molecular basis of both normal and pathological
electrophysiology. Elucidation of cardiac ion channel structure and
function has contributed to many of these advances. As a result, we may
be on the verge of an era where arrhythmia management will no longer be
dominated by trial and error based observational treatment. Our aim in
this article is to provide an overview of antiarrhythmic drug action,
linking known actions at the level of cellular electrophysiology to
clinical use. Taking particular examples, we shall also illustrate how
molecular genetic advances have shown that some rhythm disturbances can
result from specific defects in genes encoding cardiac ion channels.
Making reference to investigational drugs under study, we will also
consider the issue of whether advances in the understanding of cardiac cellular electrophysiology may improve rational approaches to antiarrhythmic drug design
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