Editorial
Intracoronary infusions and the assessment of coronary blood flow in clinical studies
| The first 150 words of the full text of this article appear below. |
Intracoronary
drug administration may be desirable for a number of reasons and is
used in therapeutic, diagnostic, interventional, and clinical research
settings. One of the main indications for intracoronary drug
administration is in the assessment of coronary blood flow either as a
guide to intervention or as a clinical research tool. There are many
methods of assessing coronary blood flow including the use of the
angiogram derived corrected TIMI (thrombolysis in myocardial
infarction) frame count1 and the rate of decorrelation of
the radiofrequency signal from intravascular ultrasound (IVUS) imaging
catheters.2 However, the most direct and widely used
method of assessing coronary blood flow is the Doppler flow wire
a
piezoelectric cell mounted on the tip of a 0.014 inch guide
wire.3
The Doppler flow wire measures coronary blood flow velocity and, in
order to measure coronary blood flow, knowledge of the cross sectional
area of the vessel is required. The latter
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